J Korean Med Assoc.  2015 Mar;58(3):209-215. 10.5124/jkma.2015.58.3.209.

Treatment for unresectable gastric cancer

• Kim TY
• Oh DY
• Bang YJ

• KMID: 2194941
• DOI: http://doi.org/10.5124/jkma.2015.58.3.209

Abstract

Systemic chemotherapy is the cornerstone of treatment for patients with advanced gastric cancer. The combination of fluoropyrimidine and platinum is the most widely used first-line treatment worldwide. In patients with HER2-positive gastric cancer, the combination of trastuzumab (an anti-HER2 monoclonal antibody) and chemotherapy is the standard-of-care. Second-line chemotherapy can also prolong patients' survival after progression; treatment options include cytotoxic chemotherapy (paclitaxel, docetaxel or irinotecan) and/or ramucirumab (an anti-VEGFR2 monoclonal antibody). A number of new targeted-agents are currently being studied, and more personalized approaches will be realized in the near future.

Keyword

Stomach neoplasms; Neoplasm metastasis; Drug therapy

MeSH Terms

Drug Therapy
Humans
Neoplasm Metastasis
Platinum
Stomach Neoplasms*
Trastuzumab
Platinum

Reference

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