J Korean Soc Emerg Med.  2015 Dec;26(6):526-533. 10.0000/jksem.2015.26.6.526.

The Analysis of Factors Related to Reaching to Therapeutic Range in Patients with Receiving Therapeutic Hypothermia after Return of Spontaneous Circulation after Out-of hospital Cardiac Arrest

• Ryou JJ
• Kim JJ
• Hwang IC
• Cho JS
• Lim YS
• Yang HJ
• Lee K

• KMID: 2191661
• DOI: http://doi.org/10.0000/jksem.2015.26.6.526

Abstract

PURPOSE
The relationship between prognostic factors and outcomes of post-cardiac arrest patients treated with therapeutic hypothermia was analyzed.
METHODS
We conducted a tertiary center retrospective study of post-cardiac arrest patients treated with therapeutic hypothermia between January 2008 and December 2012. We investigated the association of the following factors with outcomes: BMI, time to ROSC, number of vasoactive drugs, smoking, alcohol, and short time to therapeutic range in hypothermia.
RESULTS
A total of 251 patients were enrolled in this study. Large number of vasoactive drugs was a prognostic factor of 3-month mortality (adjusted OR 1.96, 95% CI:1.41-2.71, p<0.001). Obesity (BMI> or =25 kg/m2) was not associated with delayed time to therapeutic range in hypothermia. Both univariate and multivariate analysis showed that high initial BT (beta(SE)=63.64 (11.53), p<0.001) and a small number of vasoactive drugs (beta(SE)=18.66(8.74), p=0.034) were independent predictors of delayed time to therapeutic range in hypothermia.
CONCLUSION
In this study, a small number of vasoactive drugs showed a significant influence on delayed time to therapeutic range in patients receiving therapeutic hypothermia after return of spontaneous circulation after out-of-hospital cardiac arrest.

Keyword

Induced hypothermia; Heart arrest; Vasoactive drug; Outcome

MeSH Terms

Heart Arrest*
Humans
Hypothermia*
Hypothermia, Induced
Mortality
Multivariate Analysis
Obesity
Out-of-Hospital Cardiac Arrest
Retrospective Studies
Smoke
Smoking
Smoke