J Korean Assoc Oral Maxillofac Surg.  2008 Jun;34(3):350-354.

Clinical observations on mandibular chronic osteomyelitis: Combination therapy of decortication and intra-arterial infusion chemotherapy

• Kuroiwa Y
• Matsuura H
• Abe A
• Kato M
• Ariji Y
• Kurita K

Abstract

Mandibular chronic osteomyelitis with diffuse osteosclerosis is recognized as an intractable infectious disease. We emplyed decortication and intra-arterial infusion of antibiotics in 6 cases. Decortication on the affected mandible was performed with retrocatherization to the superficial temporal artery of affected side under general anesthesia. Antibiotics, IPM/CS or FOMX was used through the artery for 4-11 days. In addition, we administered FOMX, PIPC intravenously for 8-17 days. CT and MRI were taken postoperatively. The postoperative follow-up period ranged from 1 year and 6 months to 2 years and 5 months. Postoperative MR showed that bone marrow signal was recovered to approximately normal in 4 cases. High signal area of bone marrow and osteosclerosis image remained in 2 cases, but showed improvement. The results were satisfactory without recurrence in all of 6 cases.

Keyword

Chronic osteomyelitis; Diffuse osteosclerosis; Intra-arterial infusion; Antibiotic; Decortication

MeSH Terms

Anesthesia, General
Anti-Bacterial Agents
Arteries
Bone Marrow
Communicable Diseases
Follow-Up Studies
Infusions, Intra-Arterial
Mandible
Osteomyelitis
Osteosclerosis
Recurrence
Temporal Arteries
Anti-Bacterial Agents