J Korean Assoc Maxillofac Plast Reconstr Surg.  2009 Jan;31(1):1-7.

Effect of hepatocyte growth factor on the repair of defect in the articular disc in rabbit temporomandibular joint

• Kim BJ
• Seong HS
• Kim CH
• Hwang HS
• Kim GC
• Shin SH

Abstract

PURPOSE: The purpose of this study is to investigate the therapeutic use of Hepatocyte growth factor(Adv.CMV.HGF) in temporomandibular joint disc defect.
MATERIALS AND METHODS
Twelve New Zealand white rabbits, weighing 2.5 - 3.0 kg, were used in this experiment. Defects(2 mm in diameter) were created in their TMJ discs. Recombinant Adv.CMV.HGF with gelatin sponge(Gelfoam(R)) as carrier was implanted in the defects. We divided the rabbits into four batches according to the duration of the implantation - of 1, 4, 8, 12 weeks - and both left and right TMJ of each rabbit in all groups were used in the research : left joints were used as experiment group and right were control group. Each batch of rabbits was killed one, four, eight and twelve weeks after the experimentation respectively, and called Group A, B, C, and D. (Group A = 1 wk, B = 4 wks, C = 8 wks, and D = 12 wks)
RESULTS
The experimental group showed a significant increase in the number of chondroblasts and active cell differentiation at the margin of the defects. Compared to the control group, in the experiment group chondroblasts increased and chondrocytes showed a columnar arrangement, which is witnessed at the time of cell differentiation.
CONCLUSION
This study supports the case that Avd.CMV.HGF may be useful in the repair of articular disc of the rabbit TMJ.

Keyword

Hepatocyte growth factor; Articular disc; Repair of defect

MeSH Terms

Cell Differentiation
Chondrocytes
Gelatin
Hepatocyte Growth Factor
Hepatocytes
Joints
Rabbits
Temporomandibular Joint
Temporomandibular Joint Disc
Wit and Humor as Topic
Gelatin
Hepatocyte Growth Factor