J Korean Orthop Assoc.  2008 Oct;43(5):625-630. 10.4055/jkoa.2008.43.5.625.

Short Term Analgesic Effects of Intraoperative Periarticular Injection in Total Knee Arthroplasty

Affiliations
  • 1Investigation Performed at the Department of Orthopedic Surgery, Center for Joint Disease,Chonnam National University Hwasun Hospital, Jeonnam, Korea. eksong@chonnam.ac.kr

Abstract

PURPOSE: The purpose of this study was to evaluate the clinical results of intraoperative periarticular injection for osteoarthritic patients who are treated with total knee arthroplasty (TKA).
MATERIALS AND METHODS
Forty patients (2 males and 38 females) who underwent TKA under general anesthesia from January 2007 to May 2007 were enrolled in this study. We classified 20 cases to the injection group and 20 cases to the control group. For the injection group, we injected ropivacaine 40 mg, ketolocac tromethamine 2 mg, epinephrine 0.5 cc and morphine 0.8 cc to the periarticular soft tissue before inserting the prosthesis, and the same amount of saline was injected in the control group. We assessed the clinical results according to preoperative and postoperative range of motion (ROM), the visual analogue scale (VAS), and the dosage of the patient controlled anesthesia (PCA) in both groups.
RESULTS
There was no significant difference in preoperative ROM and VAS between the groups (p>0.05). However, significant differences between the groups were reported for the postoperative ROM at 6 and 12 hour. In terms of the VAS, it showed significant differences between the groups at 6 and 12 hours and at the first and second days after operation. The dosage of PCA was significantly lower at postoperative 6 and 12 hours.
CONCLUSION
For the patients treated with TKA, periarticular injection to the operation site is supposed to be an effective method at the early stage for recovery of the ROM, the postoperative pain control and to decrease of the PCA dosage.

Keyword

Periarticular injection; Total knee arthroplasty

MeSH Terms

Amides
Anesthesia
Anesthesia, General
Arthroplasty
Epinephrine
Humans
Knee
Male
Morphine
Pain, Postoperative
Passive Cutaneous Anaphylaxis
Prostheses and Implants
Range of Motion, Articular
Tromethamine
Amides
Epinephrine
Morphine
Tromethamine

Reference

1. Allen GC, St Amand MA, Lui AC, Johnson DH, Lindsay MP. Postarthroscopy analgesia with intraarticular bupivacaine/morphine. A randomized clinical trial. Anesthesiology. 1993. 79:475–480.
2. Allen HW, Liu SS, Ware PD, Nairn CS, Owens BD. Peripheral nerve blocks improve analgesia after total knee replacement surgery. Anesth Analg. 1998. 87:93–97.
Article
3. Badner NH, Bourne RB, Rorabeck CH, MacDonald SJ, Doyle JA. Intra-articular injection of bupivacaine in knee-replacement operations. Results of use for analgesia and preemptive blockade. J Bone Joint Surg Am. 1996. 78:734–738.
4. Barrington MJ, Olive D, Low K, Scott DA, Brittain J, Choong P. Continuous femoral nerve blockade or epidural analgesia after total knee replacement: a prospective randomized controlled trial. Anesth Analg. 2005. 101:1824–1829.
Article
5. Boden BP, Fassler S, Cooper S, Marchetto PA, Moyer RA. Analgesic effect of intraarticular morphine, bupivacaine, and morphine/bupivacaine after arthroscopic knee surgery. Arthroscopy. 1994. 10:104–117.
Article
6. Busch CA, Shore BJ, Bhandari R, et al. Efficacy of periarticular multimodal drug injection in total knee arthroplasty. A randomized trial. J Bone Joint Surg Am. 2006. 88:959–963.
7. Capdevila X, Barthelet Y, Biboulet P, Ryckwaert Y, Rubenovitch J, d'Athis F. Effects of perioperative analgesic technique on the surgical outcome and duration of rehabilitation after major knee surgery. Anesthesiology. 1999. 91:8–15.
Article
8. Cho WS, Ahn HS, Kim MY, Seol ES, Lee SW, Choi JW. Pain after total knee arthroplasty. J Korean Orthop Assoc. 2006. 41:129–133.
Article
9. Ethgen O, Bruyère O, Richy F, Dardennes C, Reginster JY. Health-related quality of life in total hip and total knee arthroplasty. A qualitative and systematic review of the literature. J Bone Joint Surg Am. 2004. 86:963–974.
10. Horlocker TT, Kopp SL, Pagnano MW, Hebl JR. Analgesia for total hip and knee arthroplasty: a multimodal pathway featuring peripheral nerve block. J Am Acad Orthop Surg. 2006. 14:126–135.
Article
11. Joris JL, Dubner R, Hargreaves KM. Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation? Anesth Analg. 1987. 66:1277–1281.
12. Joshi GP, McCarroll SM, Cooney CM, Blunnie WP, O'Brien TM, Lawrence AJ. Intra-articular morphine for pain relief after knee arthroscopy. J Bone Joint Surg Br. 1992. 74:749–751.
Article
13. Kang JD, Kim KY, Kim HC, Jung KC, Lee GJ. Comparison of the analgesic effect between bupivacaine and morphine by intra-articular infiltration after arthroscopic knee surgery. J Korean Knee Soc. 1998. 10:243–248.
14. Klasen JA, Opitz SA, Melzer C, Thiel A, Hempelmann G. Intraarticular, epidural, and intravenous analgesia after total knee arthroplasty. Acta Anaesthesiol Scand. 1999. 43:1021–1026.
Article
15. Lee SC, Cho HS. The analgesic effect of intraarticular bupivacaine and morphine after arthroscopic knee surgery. Korean J Anesthesiol. 1995. 28:228–233.
Article
16. Lombardi AV Jr, Berend KR, Mallory TH, Dodds KL, Adams JB. Soft tissue and intraarticular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty. Clin Orthop Relat Res. 2004. 428:125–130.
Article
17. Mauerhan DR, Campbell M, Miller JS, Mokris JG, Gregory A, Kiebzak GM. Intra-articular morphine and/or bupivacaine in the management of pain after total knee arthroplasty. J Arthroplasty. 1997. 12:546–552.
Article
18. Niskanen RO, Strandberg N. Bedside femoral block performed on the first postoperative day after unilateral total knee arthroplasty: a randomized study of 49 patients. J Knee Surg. 2005. 18:192–196.
19. Raja SN, Dickstein RE, Johnson CA. Comparison of postoperative analgesic effects of intraarticular bupivacaine and morphine following arthroscopic knee surgery. Anesthesiology. 1992. 77:1143–1147.
Article
20. Ritter MA, Koehler M, Keating EM, Faris PM, Meding JB. Intra-articular morphine and/or bupivacaine after total knee replacement. J Bone Joint Surg Br. 1999. 81:301–303.
Article
21. Shin DM, Hyun KC. The analgesic effect of intraarticular bupivacaine and morphine after arthroscopic knee surgery. J Korean Knee Soc. 1998. 10:114–118.
22. Singelyn FJ, Deyaert M, Joris D, Pendeville E, Gouverneur JM. Effects of intravenous patient-controlled analgesia with morphine, continuous epidural analgesia, and continuous three-in-one block on postoperative pain and knee rehabilitation after unilateral total knee arthroplasty. Anesth Analg. 1998. 87:88–92.
23. Smith I, Van Hemelrijck J, White PF, Shively R. Effects of local anesthesia on recovery after outpatient arthroscopy. Anesth Analg. 1991. 73:536–539.
Article
24. Song EK, Kim HS, Hur JT, Lee IG. Knee arthroscopy under intraarticular injection of bupivacaine. J Korean Orthop Assoc. 1992. 27:1691–1700.
Article
25. Stein C. Peripheral analgesic action of opioids. J Pain Symptom Manage. 1991. 6:119–124.
26. Stein C, Comisel K, Haimerl E, et al. Analgesic effect of intraarticular morphine after arthroscopic knee surgery. N Engl J Med. 1991. 325:1123–1126.
Article
27. Stein C, Millan MJ, Shippenberg TS, Peter K, Herz A. Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors. J Pharmacol Exp Ther. 1989. 248:1269–1275.
28. Vendittoli PA, Makinen P, Drolet P, et al. A multimodal analgesia protocol for total knee arthroplasty. A randomized, controlled study. J Bone Joint Surg Am. 2006. 88:282–289.
29. Watson MW, Mitra D, McLintock TC, Grant SA. Continuous versus single-injection lumbar plexus blocks: comparison of the effects on morphine use and early recovery after total knee arthroplasty. Reg Anesth Pain Med. 2005. 30:541–547.
Article
30. Wildsmith JAW, Armitage EN, McClure JH. principles and practice of reginal anesthesia. 2003. 3rd ed. USA: Chrchill Livingstone;50–52.
31. Yaksh TL. Substance P release from knee joint afferent terminals: modulation by opioids. Brain Res. 1988. 458:319–324.
Article
32. Zaric D, Boysen K, Christiansen C, Christiansen J, Stephensen S, Christensen B. A comparison of epidural analgesia with combined continuous femoral-sciatic nerve blocks after total knee replacement. Anesth Analg. 2006. 102:1240–1246.
Article
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