J Korean Assoc Maxillofac Plast Reconstr Surg.  2013 Sep;35(5):302-309.

Comparative Study on Surgical and Conservative Management of Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) in Disease Stage 2

Affiliations
  • 1Division of Oral and Maxillofacial Surgery, Department of Dentistry, Ajou University School of Medicine, Korea. arcady@ajou.ac.kr

Abstract

PURPOSE
This study evaluated the prognosis of conservative and surgical treatment according to the staging of bisphosphonate-related osteonecrosis of jaw (BRONJ) by American Association of Oral and Maxillofacial Surgeons and American Society for Bone and Mineral Research.
METHODS
We evaluated 53 patients of BRONJ who visited Department of Dentistry, Ajou University School of Medicine from May 2007 to February 2013. Twenty eight patients in stage 2, were divided into surgical and conservative groups with cessation of bisphosphonate therapy. Fifteen patients belonged to the conservative treatment group, in which mouth rinsing and antibiotics medication were done. Thirteen patients were treated with debridement or sequestrectomy, in the surgical treatment group. Each study list was analyzed by SPSS ver. 14.0 (SPSS Inc., USA) software and the favorable rate was verified by the Fisher exact test. P-values less than 0.05% were deemed significant.
RESULTS
Clinical outcome was evaluated on the basis of both clinical and radiographic findings. Of all the 28 patients of stage 2, 15 patients underwent conservative treatment and 13 patients received surgical treatment. In the surgical group, 9 of 13 (69.2%) showed good prognosis, 4 of 13 (30.7%) showed recurrence. In the conservative group, 13 of 15 (86.6%) showed no change duting the follow-up period. Two of 15 patients even showed a bad prognosis, such as pain and pus discharge, which are criteria for stage 3. P-value was 0.067 (>0.05).
CONCLUSION
The results of the present study suggests that surgical intervention is good choice against the conservative treatment, after proper drug holidays period, while further investigation is needed for a definite solution to BRONJ.

Keyword

Bisphosphonate-associated osteonecrosis of the jaw (BRONJ); Bisphosphonate; Osteonecrosis; Therapeutics

MeSH Terms

Anti-Bacterial Agents
Bisphosphonate-Associated Osteonecrosis of the Jaw
Debridement
Dentistry
Follow-Up Studies
Holidays
Humans
Jaw
Mouth
Osteonecrosis
Prognosis
Recurrence
Suppuration
Anti-Bacterial Agents
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