J Korean Neurol Assoc.
2001 Nov;19(6):654-659.
Is Brain Biopsy Rational in Shunt Operation of Normal Pressure Hydrocephalus in Elderly?
- Affiliations
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- 1Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea. dukna@smc.samsung.co.kr
- 2Department of Diagnostic pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
- 3Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
- 4Department of Neurology, Yonsei University College of Medicine, Korea.
Abstract
- Early detection of AD in its initial or preclinical stage has become increasingly important. We report a 73-year-old woman who was confirmed to have AD by a cortical biopsy performed concomitantly during a shunt operation for hydrocephalus. The triads of hydrocephalus improved after the operation, as did follow-up neuropsychological and FDG-PET findings. However, 2.5 years after the operation, the patient developed cognitive declines with abnormal behaviors, which was considered to be an evolved form of AD from the preclinical stage.
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