J Korean Med Assoc.  2008 Sep;51(9):849-855. 10.5124/jkma.2008.51.9.849.

Growth Hormone Therapy in Short Stature Children

  • 1Department of Pediatrics, Korea University College of Medicine, Korea. khlee218@kumc.or.kr


Since 1985 recombinant DNA-derived human growth hormone (hGH) became available for treatment of various growth disorders in children. GH stimulates linear growth in children with growth hormone deficiency (GHD) and also demonstrates efficacy in the treatment of Turner syndrome, chronic renal failure, Prader-Willi syndrome, and growth failure secondary to small for gestational age (SGA). Although recently FDA approved GH therapy for idiopathic short stature, the effect of GH treatment remains unclear. GH therapy is generally safe but GH has potential side effects. The decision of GH therapy in idiopathic short stature should be made individualized under consideration of the efficacy, cost-effectiveness, and psychosocial aspects, and GH therapy must be carried out by pediatric endocrinologists or experienced physicians.


Growth hormone; Efficacy; Safety; Short stature; Child

MeSH Terms

Gestational Age
Growth Disorders
Growth Hormone
Human Growth Hormone
Kidney Failure, Chronic
Prader-Willi Syndrome
Turner Syndrome
Growth Hormone
Human Growth Hormone


  • Figure 1 Normal female growth percentiles curves (dotted lines) and Turner syndrome growth curves (solid lines). Recipients of GH alone, before treatment (open circles) and after treatment (filled circles).

  • Figure 2 Mean height SDS for both GH dosage groups during 5 yr of GH treatment in SGA children (THSDS: target height SDS).

  • Figure 3 Effects of growth hormone treatment (A: growth rate, B: height SDS) in children with idiopathic short stature.

Cited by  1 articles

Comparison of Growth Hormone Treatment in Patients with Idiopathic Short Stature and Idiopathic Growth Hormone Deficiency
Seul Ah Kim, Yu Ri Choe, Eun Mi Yang, Chan Jong Kim
Chonnam Med J. 2014;50(2):63-66.    doi: 10.4068/cmj.2014.50.2.63.


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