J Korean Med Assoc.  2007 Mar;50(3):228-233. 10.5124/jkma.2007.50.3.228.

Pros and Cons of Antiaging Medicine

• Lee EJ

• KMID: 2184804
• DOI: http://doi.org/10.5124/jkma.2007.50.3.228

Abstract

Recent scientific progresses in understanding the aging process have led to an increasing interest in antiaging medicine. In contrast to the conventional medicine for the treatment of specific diseases, the antiaging treatment targets to prevent or reverse aging, disability and frailty. With the growing interest in the antiaging treatments, a large number of products like supplements, vitamins, and herbs are currently being sold under the name of "anti-aging medicine". Some complementary and alternative medicine and hormonal replacement therapy are provided by physicians. However, scientific and medical evidence supporting the effectiveness of current antiaging treatments is not sufficient. In addition, issues of safety and effectiveness are still controversial. This article focuses on the benefits and adverse effects of current anti-aging therapeutic methods and shows the future directions.

Keyword

Antiaging medicine; Hormone replacement; Growth hormone

MeSH Terms

Aging
Complementary Therapies
Growth Hormone
Vitamins
Growth Hormone
Vitamins

Reference

1. Miller RA. Extending life: scientific prospects and political obstacles. Milbank Q. 2002. 80:155–174.

2. Butler RN, Fossel M, Harman SM, Heward CB, Olshansky SJ, Perls TT, Rothman DJ, Rothman SM, Warner HR, West MD, Wright WE. Is there an antiaging medicine? J Gerontol A Biol Sci Med Sci. 2002. 57:B333–B338.

3. Fisher AL, Hill R. Ethical and legal issues in antiaging medicine. Clin Geriatr Med. 2004. 20:361–382.

4. Drazen JM. Inappropriate advertising of dietary supplements. N Engl J Med. 2003. 348:777–778.

5. Draelos ZD. Topical and oral estrogens revisited for antiaging purposes. Fertil Steril. 2005. 291–292.

6. Gruber CJ, Tschugguel W, Schneeberger C, Huber JC. Production and actions of estrogens. N Engl J Med. 2002. 346:340.

7. Shumaker SA, Legault C, Rapp SR, Thal L, Wallace RB, Ockene JK, Hendrix SL, Jones BN 3rd, Assaf AR, Jackson RD, Kotchen JM, Wassertheil-Smoller S, Wactawski-Wende J. WHIMS Investigators. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA. 2003. 289:2651–2662.

8. Nelson HD, Humphrey LL, Nygren P, Teutsch SM, Allan JD. Postmenopausal hormone replacement therapy: scientific review. JAMA. 2002. 288:872–881.

9. Morley JE, Perry HM 3rd. Androgen deficiency in aging men: role of testosterone replacement therapy. J Lab Clin Med. 2000. 1(9):370–378.

10. Lee EJ, Lee D, Lee YS. Clinical experiences of testosterone replacement therapy in frail elderly patients. J Kor Geriatr Soc. 2003. 7:288–294.

11. Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL, Bhasin S. Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci. 2005. 60:1451–1457.

12. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990. 323:1–6.

13. Blackman MR, Sorkin JD, Munzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, Jayme J, O'Connor KG, Christmas C, Tobin JD, Stewart KJ, Cottrell E, St Clair C, Pabst KM, Harman SM. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA. 2002. 288:2282–2292.

14. Perls TT, Reisman NR, Olshansky SJ. Provision or distribution of growth hormone for "antiaging": clinical and legal issues. JAMA. 2005. 294:2086–2090.

15. Liu H, Bravata DM, Olkin I, Nayak S, Roberts B, Garber AM, Hoffman AR. Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann Intern Med. 2007. 146:104–115.

16. Horani MH, Morley JE. Hormonal fountains of youth. Clin Geriatr Med. 2004. 1(9):275–292.

17. Kamel NS, Gammack J, Cepeda O, Flaherty JH. Antioxidants and hormones as antiaging therapies: high hopes, disappointing results. Cleve Clin J Med. 2006. 1(9):1049–1056. 1058

18. Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry. 2006. 14:1032–1040.

19. Masoro EJ. Overview of caloric restriction and ageing. Mech Ageing Dev. 2005. 126:913–922.

20. Olshansky SJ, Hayflick L, Carnes BA. Position statement on human aging. J Gerontol A Biol Sci Med Sci. 2002. 57:B292–B297.

21. Grossman T. Latest advances in antiaging medicine. Keio J Med. 2005. 54:85–94.