J Korean Foot Ankle Soc.  2014 Dec;18(4):159-164. 10.14193/jkfas.2014.18.4.159.

Effect of Antiplatelets in Diabetic Peripheral Vasculopathy: Comparison by Ankle-Brachial Index and Peak Wave Velocity

• Park SJ

• KMID: 2181635
• DOI: http://doi.org/10.14193/jkfas.2014.18.4.159

Abstract

PURPOSE
The purpose of this study is to confirm the effect of antiplatelet drugs in diabetic peripheral vasculopathy in diabetic foot patients.
MATERIALS AND METHODS
We designed a retrospective study in diabetic foot patients with diabetic peripheral vasculopathy. From October 2007 to December 2013, 278 cases in 139 patients who took antiplatelet drugs over at least a six-month period were included in this study. We categorized these patients according to the type of drug used. The efficacy of antiplatelet drugs was evaluated using anklebrachial index (ABI) and pulse wave velocity (PWV).
RESULTS
Only the aspirin group showed a statistically significant increase of ABI after antiplatelet therapy (1.10+/-0.12 to 1.12+/-0.11). In addition, only the cilostazol group showed a statistically significant decrease of PWV after antiplatelet therapy (1,701.20+/-396.56 to 1,627.42+/-324.98).
CONCLUSION
Aspirin and cilostazol may be used in treatment of diabetic peripheral vasculopathy, whereas dual antiplatelet therapy with aspirin and clopidogrel has no specific benefits in diabetic peripheral vasculopathy.

Keyword

Diabetes; Diabetic angiopathy; Platelet aggregation inhibitors

MeSH Terms

Ankle Brachial Index*
Aspirin
Diabetic Angiopathies
Diabetic Foot
Humans
Platelet Aggregation Inhibitors
Pulse Wave Analysis
Retrospective Studies
Aspirin
Platelet Aggregation Inhibitors

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