J Korean Androl Soc.
1991 Dec;9(2):91-94.
The gonadotropin response of men with varicoceles to gonadotropin- releasing hormone
- Affiliations
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- 1Department of Urology, Korea University College of Medicine, Seoul, Korea.
- 2Department of Urology, Capital Armed Forces General Hospital, Seoul, Korea.
Abstract
- For aim of evalution of hypothalamic-pituitary-testicular axis in varicocele, the serum gonadotropin responses to 100microgram of intravenously administered gonadotropin-releasing hormone (GnRH) were studied over 60 minutes. The study was carried in three groups of men : oligospermic men with varicoceles, normospermic men with varicoceles and normal fertile men. Oligospermic men with varicoceles had higer preinjection gonadotropin levels than normal fertile men, normospermic men with varicoceles had higer LH levels than normal fertile men, oligospermic men with varicoceles higher FSH levels than normospermic men with varicoceles. Following the injection of GnRH, the oligospermic men with varicoceles showed excessive in FSH levels and a slower return to preinjection values as compared with the other tow groups. The oligospermic men with varicoceles and normospermic men with varicoceles had a similar FSH response, but the oligospermic men with varicoceles showed a slower return to baseline FSH levels than normospermic men with varicoceles. These results suggest that oligospermic men with varicoceles may have a pantesticular defect in testosterone synthesis and spermatogenesis.
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