J Korean Acad Rehabil Med.
2006 Aug;30(4):322-327.
The Findings of 1H Magnetic Resonance Spectroscopy in Children with Mental Retardation or Autism
- Affiliations
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- 1Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Korea. iysung@www.amc.seoul.kr
- 2Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Korea.
- 3Department of Nuclear Magnetic Resonance, Asan Institute for Life Sciences, Korea.
- 4Department of Radiology, Sungkyunkwan University School of Medicine, Korea.
Abstract
OBJECTIVE
To investigate the findings of patients with autism or mental retardation shown in 1H magnetic resonance spectroscopy (1H MRS) and the correlation between findings in 1H MRS and degree of language developmental delay. METHOD: 1H MRS was performed in thirty five patients with autism or mental retardation. [N-Acetylaspartate (NAA)/ Creatine (Cr)], [Choline (Cho)/Cr], and [Myoinositol (mI)/ Cr] were measured and compared with those of control group. Also the correlation between 1H MRS findings and the degree of language developmental delay was investigated.
RESULTS
Increased [Cho/Cr] was shown in parietal white matter and frontal gray matter in patients with autism and mental retardation. No significant differences were revealed in any metabolite ratio between mental retardation and autism. There were no significant correlations between the degree of language developmental delay and metabolite ratios.
CONCLUSION
Myelin degeneration in parietal white matter and fronal gray matter could be related to autism and mental retardation.
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