J Breast Cancer.  2016 Mar;19(1):87-91. 10.4048/jbc.2016.19.1.87.

Metastatic Osteosarcoma to the Breast Presenting as a Densely Calcified Mass on Mammography

Affiliations
  • 1Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea. lvjenny@yuhs.ac
  • 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Osteosarcoma most commonly metastasizes to the lung or the skeleton, and metastatic osteosarcoma to the breast is very rare, with only a few cases reported. Due to its rarity, little has been reported about its imaging features. In this report, we represent a 58-year-old woman with metastatic osteosarcoma to the right breast from a tibial osteosarcoma. The imaging features of the metastatic osteosarcoma to the breast by using dedicated breast imaging modalities are described. Although rare, metastatic osteosarcoma to the breast should be considered when dense calcified masses with suspicious features are seen on breast imaging in patients with a history of osteosarcoma.

Keyword

Breast; Mammography; Neoplasm metastasis; Osteosarcoma; Ultrasonography

MeSH Terms

Breast*
Female
Humans
Lung
Mammography*
Middle Aged
Neoplasm Metastasis
Osteosarcoma*
Skeleton
Ultrasonography

Cited by  1 articles

Invasive Breast Cancer Presenting as a Mass Replaced by Calcification on Mammography: A Report of Two Cases
Joo Hee Jeun, Jin Hwa Lee, Eun Cho, Su Jin Kim, Eun Hwa Park, Kyung Do Byun
J Korean Soc Radiol. 2019;80(3):591-597.    doi: 10.3348/jksr.2019.80.3.591.


Reference

1. Yeh CN, Lin CH, Chen MF. Clinical and ultrasonographic characteristics of breast metastases from extramammary malignancies. Am Surg. 2004; 70:287–290.
2. Mun SH, Ko EY, Han BK, Shin JH, Kim SJ, Cho EY. Breast metastases from extramammary malignancies: typical and atypical ultrasound features. Korean J Radiol. 2014; 15:20–28.
Article
3. Basu S, Moghe SH, Shet T. Metastasis of humeral osteosarcoma to the contralateral breast detected by 99mTc-MDP skeletal scintigraphy. Jpn J Radiol. 2009; 27:455–457.
Article
4. Vieira SC, Tavares MB, da Cruz Filho AJ, Sousa RB, Dos Santos LG. Metastatic osteosarcoma to the breast: a rare case. J Obstet Gynaecol Res. 2010; 36:891–893.
Article
5. Chan RS, Kumar G, Vijayananthan AA. Rare occurrence of bilateral breast and peritoneal metastases from osteogenic sarcoma. Singapore Med J. 2013; 54:e68–e71.
Article
6. Roebuck DJ, Sato JK, Fahmy J. Breast metastasis in osteosarcoma. Australas Radiol. 1999; 43:108–110.
Article
7. Kim SJ, Choi JA, Lee SH, Choi JY, Hong SH, Chung HW, et al. Imaging findings of extrapulmonary metastases of osteosarcoma. Clin Imaging. 2004; 28:291–300.
Article
8. Salah S, Ahmad R, Sultan I, Yaser S, Shehadeh A. Osteosarcoma with metastasis at initial diagnosis: current outcomes and prognostic factors in the context of a comprehensive cancer center. Mol Clin Oncol. 2014; 2:811–816.
Article
9. Surov A, Fiedler E, Holzhausen HJ, Ruschke K, Schmoll HJ, Spielmann RP. Metastases to the breast from non-mammary malignancies: primary tumors, prevalence, clinical signs, and radiological features. Acad Radiol. 2011; 18:565–574.
10. Momoi H, Wada Y, Sarumaru S, Tamaki N, Gomi T, Kanaya S, et al. Primary osteosarcoma of the breast. Breast Cancer. 2004; 11:396–400.
Article
11. Dragoumis D, Bimpa K, Assimaki A, Tsiftsoglou A. Primary osteogenic sarcoma of the breast. Singapore Med J. 2008; 49:e315–e317.
12. Trihia H, Valavanis C. Histopathology and molecular pathology of bone and extraskeletal osteosarcomas. In : Agarwal M, editor. Osteosarcoma. Rijeka: InTech;2012.
13. Leibl S, Gogg-Kammerer M, Sommersacher A, Denk H, Moinfar F. Metaplastic breast carcinomas: are they of myoepithelial differentiation? Immunohistochemical profile of the sarcomatoid subtype using novel myoepithelial markers. Am J Surg Pathol. 2005; 29:347–353.
Article
14. Geller DS, Gorlick R. Osteosarcoma: a review of diagnosis, management, and treatment strategies. Clin Adv Hematol Oncol. 2010; 8:705–718.
15. Bielack S, Carrle D, Casali PG. ESMO Guidelines Working Group. Osteosarcoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2009; 20:Suppl 4. 137–139.
Article
Full Text Links
  • JBC
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2025 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr