J Breast Cancer.  2009 Jun;12(2):117-120. 10.4048/jbc.2009.12.2.117.

A Mucocele-Like Tumor of the Breast Associated with Ductal Carcinoma In Situ and Mucinous Carcinoma: A Case Report

• Cho JS
• Ryu HS
• Ro HW
• Lim HS
• Park MH
• Lee JS
• Yoon JH
• Jegal YJ

• KMID: 2175213
• DOI: http://doi.org/10.4048/jbc.2009.12.2.117

Abstract

A Mucocele-like tumor (MLT) of the breast is a rare lesion and is pathologically characterized by mucin-filled cysts and extravasated mucin present in the adjacent stroma. Since the first report of an MLT of the breast by Rosen in 1986, an MLT has been considered as part of a diverse spectrum of pathological lesions including benign tumors, atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and mucinous carcinomas. We described a case of an MLT of the breast associated with DCIS and a mucinous carcinoma in a 46-year-old female patient who was treated with a left modified radical mastectomy and a sentinel lymph node biopsy. This case supports the concept of a spectrum of pathological lesions for an MLT, including benign lesions, columnar hyperplasia, ADH, DCIS and mucinous carcinomas.

Keyword

Breast; Ductal Carcinoma in situ; Mucinous carcinoma; Mucocele-like tumor

MeSH Terms

Adenocarcinoma, Mucinous
Breast
Carcinoma, Ductal
Carcinoma, Intraductal, Noninfiltrating
Female
Humans
Hyperplasia
Mastectomy, Modified Radical
Middle Aged
Mucins
Nitriles
Pyrethrins
Sentinel Lymph Node Biopsy
Mucins
Nitriles
Pyrethrins

Figure

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  Figure 1 A 0.9 cm size mucin-filled cystic lesion (mucocele like tumor) is adjacent to 1.8 cm size heterogeneous ill defined mucinous carcinoma on breast ultrasonography.

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  Figure 2 Multiple high signal intensity lesions in left upper outer breast on T2 weighted MR images, and subsequent dynamic contrast enhanced T1 weighted MR images revealed 0.6 cm and 1.7 cm size peripheral delayed enhancing lesions.

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  Figure 3 A mucoele-like tumor with ductal carcinoma in situ (DCIS) and mucinous carcinoma (A). Low magnification view showing mucin-filled epithelial lined cysts and extravasated mucin in the stroma (B). Columnar cell epithelium in the cyst (C). Micropapillary DCIS (D). Low magnification view showing mucinous carcinoma (A, D, H&E stain).

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