J Korean Cancer Assoc.  1999 Dec;31(6):1087-1093.

Prognostic Significance of VEGF in Human Stomach Cancer

• Han GS
• Cha SJ
• Park YK
• Chi KC
• Park SJ
• Lim HM
• Park SI
• Park US

Abstract

PURPOSE: Angiogenesis plays an important role in the growth, progression and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) was thought to be one such angiogenic factor and was also thought to be a selective mitogen for endothelial cells. The purpose of this retrospective study was to evaluate for prognostic significance of VEGF in stomach cancer.
MATERIALS AND METHODS
The sections of formalin-fixed, paraffin embedded from 55 stomach cancer were stained immunohistochemically for VEGF. The rate of VEGF expression and correlation between expression of VEGF and other prognostic factor of stomach cancer were studied.
RESULTS
There were 20 cases (36.4%) of VEGF-positive and 35 cases (63.6%) of VEGF- negative. There were no significant difference between VEGF expression and the histologic type, differentiation, depth of invasion of histologic stage, lymph node involvement. The frequency of hepatic recurrence was higher in patients with VEGF-positive tumor than that af patient with negative tumor (p=0.007). The prognosis of the patients with VEGF positive tumor was worse than that of patients with VEGF negative tumor (p=0.0214).
CONCLUSION
There was a closely significant between positive expression of VEGF and a high incidence of hepatic metastasis, low survival rate. The expression of VEGF could be considered to be one of useful prognostic factor in human gastric carcinoma

Keyword

VEGF; Stomach cancer; Prognosis

MeSH Terms

Angiogenesis Inducing Agents
Endothelial Cells
Humans*
Incidence
Lymph Nodes
Neoplasm Metastasis
Paraffin
Prognosis
Recurrence
Retrospective Studies
Stomach Neoplasms*
Stomach*
Survival Rate
Vascular Endothelial Growth Factor A*
Angiogenesis Inducing Agents
Paraffin
Vascular Endothelial Growth Factor A