Intest Res.  2016 Jan;14(1):30-36. 10.5217/ir.2016.14.1.30.

Clinical features of Crohn's disease in Korean patients residing in Busan and Gyeongnam

• Lee EJ
• Kim TO
• Song GA
• Lee JH
• Kim HW
• Jee SR
• Park SJ
• Kim HJ
• Park JH

• KMID: 2174507
• DOI: http://doi.org/10.5217/ir.2016.14.1.30

Abstract

BACKGROUND/AIMS
Crohn's disease (CD) is a chronic inflammatory bowel disease that presents with variable features and repeated disease aggravation. The incidence of CD is increasing in Korea. We evaluated the clinical features of CD in a study population in Busan and Gyeongnam, Korea.
METHODS
A hospital-based analysis included 619 patients diagnosed with CD between March 1986 and February 2013 from seven tertiary care hospitals in Busan and Gyeongnam. Individual case records were reviewed with regard to age at diagnosis, sex, disease location, disease behavior, and medical and surgical treatments received during the follow-up period.
RESULTS
The cumulative frequency of patients diagnosed with CD revealed a continued increase in the number of cases reported yearly. The male-to-female ratio was 2.5:1 and the median age at diagnosis was 24 years. At diagnosis, 114 (18.4%) had isolated small bowel disease, 144 (23.3%) had isolated colonic disease, and 358 patients (57.8%) presented with disease in the small bowel and colon. The number of patients presenting with stricturing or penetrating disease behavior was 291 (47%) at the final evaluation. In total, 111 (17.9%) patients underwent intestinal resections.
CONCLUSIONS
A continued increase in the number of patients diagnosed with CD was found in Busan and Gyeongnam as observed in other regions. We report results similar to that of other Korean studies in terms of sex distribution, age, and location of disease.

Keyword

Crohn disease; Inflammatory bowel diseases; Clinical features; Intestinal resection

MeSH Terms

Busan*
Colon
Colonic Diseases
Crohn Disease*
Diagnosis
Follow-Up Studies
Humans
Incidence
Inflammatory Bowel Diseases
Korea
Sex Distribution
Tertiary Healthcare

Figure

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  Fig. 1 Cumulative frequency. The number of cases of patients diagnosed with CD increased over time.

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  Fig. 2 Age and sex distribution at diagnosis of CD. The incidence of the 20–29-year-old age group for male and female was highest.

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  Fig. 3 Cumulative probability of intestinal resection during follow-up. It was 10.3%, 14.0%, 16.7%, and 36.9% at 1, 5, 10 and 20 years.

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