Intest Res.  2012 Oct;10(4):397-399. 10.5217/ir.2012.10.4.397.

A Case of Adenocarcinoma of the Transverse Colon with Humoral Hypercalcemia of Malignancy

• Lee JG
• Han DS
• Kim JH
• Kim YS
• Kim HS
• Jeong JY
• Pyo JY
• Jeon YC
• Sohn JH

• KMID: 2174259
• DOI: http://doi.org/10.5217/ir.2012.10.4.397

Abstract

Hypercalcemia is a common electrolyte imbalance in patients with malignancy. Approximately 80% of hypercalcemia is associated with humoral hypercalcemia of malignancy (HHM), but occurs rarely in colorectal carcinomas. A 72-year-old man was admitted with abdominal pain and bowel habit change. Colonoscopy showed a malignant tumor in the transverse colon. Laboratory data showed an elevated serum calcium level (11.6 mg/dL) and elevated parathyroid hormone-related peptide level (12.2 pmol/L). Histology showed poorly differentiated adenocarcinoma. We infused intravenous normal saline, furosemide and pamidronate. The serum calcium level was subsequently normalized. However, the patient died from cancer progression 10 days later. With a review of the relevant literature, we report a case of adenocarcinoma of the transverse colon with HHM.

Keyword

Colonic Neoplasms; Hypercalcemia; Water-Electrolyte Imbalance

MeSH Terms

Abdominal Pain
Adenocarcinoma
Aged
Calcium
Colon, Transverse
Colonic Neoplasms
Colonoscopy
Colorectal Neoplasms
Diphosphonates
Furosemide
Humans
Hypercalcemia
Paraneoplastic Syndromes
Parathyroid Hormone-Related Protein
Water-Electrolyte Imbalance
Calcium
Diphosphonates
Furosemide
Hypercalcemia
Paraneoplastic Syndromes
Parathyroid Hormone-Related Protein