Intest Res.  2012 Oct;10(4):397-399. 10.5217/ir.2012.10.4.397.

A Case of Adenocarcinoma of the Transverse Colon with Humoral Hypercalcemia of Malignancy

Affiliations
  • 1Department of Internal Medicine, Hanyang University College of Medicine, Guri, Korea. hands@hanyang.ac.kr
  • 2Department of Pathology, Hanyang University College of Medicine, Guri, Korea.

Abstract

Hypercalcemia is a common electrolyte imbalance in patients with malignancy. Approximately 80% of hypercalcemia is associated with humoral hypercalcemia of malignancy (HHM), but occurs rarely in colorectal carcinomas. A 72-year-old man was admitted with abdominal pain and bowel habit change. Colonoscopy showed a malignant tumor in the transverse colon. Laboratory data showed an elevated serum calcium level (11.6 mg/dL) and elevated parathyroid hormone-related peptide level (12.2 pmol/L). Histology showed poorly differentiated adenocarcinoma. We infused intravenous normal saline, furosemide and pamidronate. The serum calcium level was subsequently normalized. However, the patient died from cancer progression 10 days later. With a review of the relevant literature, we report a case of adenocarcinoma of the transverse colon with HHM.

Keyword

Colonic Neoplasms; Hypercalcemia; Water-Electrolyte Imbalance

MeSH Terms

Abdominal Pain
Adenocarcinoma
Aged
Calcium
Colon, Transverse
Colonic Neoplasms
Colonoscopy
Colorectal Neoplasms
Diphosphonates
Furosemide
Humans
Hypercalcemia
Paraneoplastic Syndromes
Parathyroid Hormone-Related Protein
Water-Electrolyte Imbalance
Calcium
Diphosphonates
Furosemide
Hypercalcemia
Paraneoplastic Syndromes
Parathyroid Hormone-Related Protein
Full Text Links
  • IR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr