J Korean Breast Cancer Soc.  1998 Jun;1(1):131-138. 10.4048/jkbcs.1998.1.1.131.

Histologic Grading and Biomarkers of Ductal Carcinoma In Situ

• Lee SJ
• Kim DS

• KMID: 2173703
• DOI: http://doi.org/10.4048/jkbcs.1998.1.1.131

Abstract

We analyzed the clinical features of 30 cases of pure ductal carcinoma in situ (DCIS). And to compare the histologic grading system for DCIS. we graded the DCIS according to the Lagio's, Poller's, Silverstein's and Holland's classification. In order to compare histologic grading and status of biomarkers such as estrogen receptor, progesterone receptor, c-erbB-2, p53 and ki 67, immunohistochemical method for biomarkers was used. The most common pure and mixed type were cribriform and cribriform and micropapillary DCIS, respectively. Distribution of histologic grading according to the Lagio's, Holland's and Silverstein's except more Poller's classification were similar, and about 2/3 of cases were high grade. High grade lesions more freguently lack estrogen and progesterone receptors (p<0.05), have overexpression of the c-erbB-2 and p53 (p<0.05). In summery, adequate histologic grading and biomarkers were very important in DCIS.

Keyword

Breast carcinoma; DCIS; Histologic grading

MeSH Terms

Biomarkers*
Breast Neoplasms
Carcinoma, Ductal*
Carcinoma, Intraductal, Noninfiltrating*
Classification
Estrogens
Receptors, Progesterone
Estrogens
Receptors, Progesterone