Good Responders in Primary Chemotherapy on the Breast Cancer

Chang, Eil Sung; Kim, Jang Yong; Pack, Hae Duck

Abstract

The therapeutic responsibles of the inductive preoperative chemotherapy on the breast cancer were variable and we examined relations between age, chemotherapeutic regimens, size of tumor, mammographic and sonographic findings, hormoal factors in tumor mass and responsibles of the inductive chemotherapy in 44 cases of good responders among 101 cases of breast cancer patient underwent preoperative inducuive chemotherapy in 44 cases of good responders among 101 cases of breast cancer patient underwent preoperative inductive Chemotherapy at Chungnam National University Hospital, from Jan. 1993 to Dec. 1997. The results of the study were obtained as follows: 1) The premanopause women were 29 patients (28.7%), postmanopause women were 15 patient (48.4%) and the response was good in postmanopause women than premanopause women (p=0.06). 2) The good responders were underwent underwent MMM regimen (46.3%) compare with FAC regimen (38.2%)(p=0.07). 3) The result was good in smaller maximum diameter of initial tumor mass than larger one. There were 86.7% of responders in less than 2cm of tumor size, 42.6% in 2-4cm and 20.2% in more than 4 cm(p=0.001). 4) The relations between degree of marginations, density, microcalcification, spiculation on mammography and sonography and responsibles of inductive chemotherapy were no significant one.