J Korean Breast Cancer Soc.  1999 Jun;2(1):14-20. 10.4048/jkbcs.1999.2.1.14.

Correlation of Breast Cancer with Atypical Ductal Hyperplasia on Fine-needle Aspiration Cytology Speciemens

• Kim LS
• Sohn JH
• Kim JJ
• Kim JH
• Cha KH
• Kim S
• Choi CS
• Lee BH

• KMID: 2173660
• DOI: http://doi.org/10.4048/jkbcs.1999.2.1.14

Abstract

PURPOSE: Atypical ductal hyperplasia (ADH) is a lesion with significant malignant potential. We evaluated the prevalence of breast carcinoma in surgical breast biopsies performed on palpable breast lesions diagnosed initially as ADH by fine needle aspiration cytology (FNAC).
MATERIALS AND METHODS
Between January 1, 1996 and December 31, 1997, 942 patients performed FNAC at the Department of Surgery and Pathology, College of Medicine, Hallym University and Department of Surgery, Central Gil Hospital were analyzed. ADH was found in 46(4.9%) of 942 patients and surgical excision subsequently was performed in 39 of these cases. In these 39 cases, cytologic and histopathologic results from FNAC and surgical biopsies were reviewed and correlated.
RESULTS
Histopathologic study of the 39 surgically excised lesions diagnosed as ADH in their fine needle aspiration cytology specimens showed breast cancer in 15 cases(38.5%), ADH in 11 cases (28.2%) and benign disease in 13 cases (33.3%).
CONCLUSION
In our patient population, 15 cases(38.5%) of 39 patients with ADH at FNAC had a breast cancer. Therefore the fine needle aspiration cytology finding of ADH warrants a recommendation for an excisional biopsy.

Keyword

ADH; Prevalence; Breast cancer; FNAC

MeSH Terms

Biopsy
Biopsy, Fine-Needle*
Breast Neoplasms*
Breast*
Humans
Hyperplasia*
Pathology
Prevalence