Blood Res.  2015 Sep;50(3):179-181. 10.5045/br.2015.50.3.179.

A case of simultaneous presentation of symptomatic PCM and MDS unrelated to prior chemotherapy

Affiliations
  • 1Department of Laboratory Medicine, Pusan National University Hospital, Busan, Korea. korailman-1@hanmail.net
  • 2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
  • 3Division of Hematology-Oncology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea.

Abstract

No abstract available.


MeSH Terms

Drug Therapy*

Figure

  • Fig. 1 Bone marrow findings showing both features of plasma cell myeloma and myelodysplastic syndrome. The arrows indicate megakaryocytes with separated (A) and hypolobulated nuclei (B, C), and erythroblasts with binucleation (C, lower side) and delayed mitosis (D), respectively. Bone marrow biopsy revealed diffuse infiltration of plasma cells (E) that were CD138 positive (F).


Reference

1. Gertz MA, Terpos E, Dispenzieri A, et al. Therapy-related myelodysplastic syndrome/acute leukemia after multiple myeloma in the era of novel agents. Leuk Lymphoma. 2015; 56:1723–1726. PMID: 25284489.
Article
2. Pemmaraju N, Shah D, Kantarjian H, et al. Characteristics and outcomes of patients with multiple myeloma who develop therapy-related myelodysplastic syndrome, chronic myelomonocytic leukemia, or acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015; 15:110–114. PMID: 25107338.
Article
3. Reddi DM, Lu CM, Fedoriw G, et al. Myeloid neoplasms secondary to plasma cell myeloma: an intrinsic predisposition or therapy-related phenomenon? A clinicopathologic study of 41 cases and correlation of cytogenetic features with treatment regimens. Am J Clin Pathol. 2012; 138:855–866. PMID: 23161720.
4. Malhotra J, Kremyanskaya M, Schorr E, Hoffman R, Mascarenhas J. Coexistence of myeloproliferative neoplasm and plasma-cell dyscrasia. Clin Lymphoma Myeloma Leuk. 2014; 14:31–36. PMID: 24220620.
Article
5. Várkonyi J, Jánosy J, Gopcsa L, et al. Myelodysplasia and multiple myeloma or monoclonal gammopathy. A non-fortuitous coexistence. Hungarian Med J. 2007; 1:107–112.
Article
6. Tsiara S, Economou G, Panteli A, Isaakidis P, Kapsali E, Bourantas KL. Coexistence of myelodysplastic syndrome and multiple myeloma. J Exp Clin Cancer Res. 1999; 18:565–566. PMID: 10746986.
7. Yoshida Y, Oguma S, Ohno H, et al. Co-occurrence of monoclonal gammopathy and myelodysplasia: a retrospective study of fourteen cases. Int J Hematol. 2014; 99:721–725. PMID: 24687918.
Article
Full Text Links
  • BR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr