J Korean Acad Child Adolesc Psychiatry.
2012 Oct;23(Suppl):S12-S23.
Efficacy of OROS Methylphenidate for the Treatment of ADHD
- Affiliations
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- 1Department of Psychiatry, Kwandong University College of Medicine, Myongji Hospital, Goyang, Korea.
- 2Department of Psychiatry, College of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Korea.
- 3Department of Psychiatry, College of Medicine, Chungbuk National University, Cheongju, Korea.
- 4Seoul Brain Research Institute, Seoul, Korea.
- 5Department of Psychiatry, Soonchunhyang University, College of Medicine, Bucheon Hospital, Bucheon, Korea.
- 6Department of Psychiatry, Chung-Ang University Hospital, Seoul, Korea.
- 7Department of Psychiatry and Institute of Behavioral Science in Medicine, College of Medicine, Yonsei University, Seoul, Korea. dhsong@yuhs.ac
Abstract
- Attention-deficit/hyperactivity disorder (ADHD) is one of the common psychiatric problems in childhood. The symptoms of ADHD tend to last for adulthood and the patients suffer from various comorbid problems and functional impairments. Methylphenidate (MPH) is the first choice of pharmacotherapy for ADHD and many researches have demonstrated its efficacy. We reviewed the clinical trials for efficacy of MPH focusing on Osmotic-Controlled Release Oral delivery System Methylphenidate (OROS MPH). It was identified that MPH improved core symptom of ADHD, peer relationship and health related quality of life and might improve various aspects of cognitive function. It was proved that the efficacy of OROS MPH was better than placebo and comparable to immediate release MPH (IR MPH) dosed three times daily in various studies. Especially, parent's preference of OROS MPH was better than IR MPH. The efficacy of MPH for academic achievement was equivocal. Long-term efficacy of OROS MPH was also inconclusive and further study is necessary.
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