Chonnam Med J.  1999 Mar;35(1):29-36.

Lipid, Lipoprotein and Apolipoprotein Abnomalities in Patients with Chronic Renal Failure on Maintenance Hemodialysis

• Cho KS
• Ahn HB
• Kim DY
• Lee SY
• Cho BH
• Suh SP

Abstract

Hypertriglyceridemia has been considered a characteristic plasma lipid abnormality in hemodialysis patients with chronic renal failure (CRF), but is relatively common in this population. Also renal dyslipidemia may contribute to the developement of atherosclerosis in hemodialysis patients. so we examined serum lipid, lipoprotein and apolipoprotein levels to compare differences of these abnormalities in 34 patients with normotriglyceridemia(NTG), 11 patients with hypertriglyceridemia (HTG) and 47 healthy controls. In comparison with control, the NTG group had significantly decreased level of total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C). By the way, HTG group had significantly increased triglyceride (TG) and TC/HDL-C ratio, considered to represent the atherogenic indicater, and had decrease of HDL-C and LDL-C (P<0.001), with significant increase of TG and TC/HDL-C ratio compared with NTG group. In the apolipoprotein profiles, both patient gorups showed the decrease of apolipoprotein (apo) A-I, apoB and apoA-I/apoC-III ratio and the increase of apoC-III and apoC-III/apoE ratio compared with control (P<0.001). Especially, HTG group had significantly increased apoC-III and apoA-I/apoC-III ratio compared with NTG group. These results suggest that abnormalities of the potentially atherogenic lipids and lipoproteins may contribute to the high incidence of cardiovascular complications and the progression of renal diseases in the patients with CRF on maintenance hemodialysis.

Keyword

Hemodialysis; Lipoprotein; Triglyceridemia

MeSH Terms

Apolipoprotein C-III
Apolipoproteins B
Apolipoproteins*
Atherosclerosis
Cholesterol
Dyslipidemias
Humans
Hypertriglyceridemia
Incidence
Kidney Failure, Chronic*
Lipoproteins*
Plasma
Renal Dialysis*
Triglycerides
Apolipoprotein C-III
Apolipoproteins
Apolipoproteins B
Cholesterol
Lipoproteins