Chonnam Med J.  2005 Apr;41(1):102-110.

Effects of Coil and Tissue Adhesive as Occlusion Material on the Respiratory Tract of Rabbit

• Kang MS
• Kim JK
• Chang NK
• Kang HK

Abstract

This study was to evaluate the radiologic and pathologic findings of bronchial trees which were occluded by coil or tissue adhesive. Eighteen rabbits were used. The embolizing coil or the tissue adhesive were used as the occlusive agents. Each group of 9 rabbits were followed at 3 hours (H), 3 days (D), and 1 week (W). After chest radiography and HRCT, the lungs and heart were taken. On chest radiography, there were no abnormal findings in all groups. On HRCT examination, coil groups showed focal atelectasis and adjacent pneumonic infiltration at 3 D and became more extensive at 1W. Tissue adhesive group showed deposition of the mixture in bronchiolar trees. At 3 D and 1 W, mild edema, pneumonic infiltration and bronchiolitis were observed, and were more severe at 1 W. On pathologic examinations, coil group showed mild alveolar congestion and alveolar septal thickening at 3 H and tissue adhesive group showed severe focal bronchiolar destructions, acute hemorrhages and severe edema. At 3 D, coil group showed mild emphysema, alveolar septal thickening and infiltrations of neutrophils, and tissue adhesive group showed bronchopneumonia findings. At 1 W, coil group showed focal emphysema and atelectasis with more aggravation of septal thickening, and tissue adhesive group showed focal edema, aggravations of bronchiolar destruction. The occlusive coil in the rabbit's bronchial trees caused less inflammatory reactions but more extensive atelectasis than the tissue adhesive did. It is recommended that the tissue adhesive is used for occlusion of small-sized bronchioles and the occlusive coil for more larger-sized bronchioles.

Keyword

Bronchial tree occlusion; Embolizing coils; Tissue adhesive

MeSH Terms

Bronchioles
Bronchiolitis
Bronchopneumonia
Edema
Emphysema
Estrogens, Conjugated (USP)
Heart
Hemorrhage
Lung
Neutrophils
Pulmonary Atelectasis
Pulmonary Emphysema
Rabbits
Radiography
Respiratory System*
Thorax
Tissue Adhesives*
Estrogens, Conjugated (USP)
Tissue Adhesives