Chonnam Med J.  2008 Dec;44(3):132-136. 10.4068/cmj.2008.44.3.132.

Effects of Renewal SS-cream on the Bulbocavernosus Reflex (BCR) in Rabbits

  • 1Andrology Center of Peking University First Hospital, Peking University, Institute of Urology Peking University, Beijing, China.


Renewal SS-cream is a topical agent modified from the original SS-cream which is effective in the treatment of premature ejaculation. In this study, the efficacy of renewal SS-cream on premature ejaculation caused by the bulbocavernosus reflex (BCR) was investigated in rabbits. Sixty male New Zealand white rabbits (weights: 2.5~3.0 kg) were divided into 3 groups randomly. Either renewal or original SS-cream or placebo (provided by CJ Co. LTD) was topically applied to the glans penis of rabbits in a double-blind manner. The bulbocavernosus reflex (BCR) was elicited by electrical stimulation of the glans penis. The latency of BCR (BCRLT) and the amplitude of BCR (BCRAP) were recorded on an electrophysiograph (Poseidomn, Shanghai, China) before and at 10, 30 and 60 min after application of the test agents. Representative tracings of BCRLT and BCRAP were recorded and analyzed. The mean BCRLT values were significantly prolonged in post-application groups of SS-cream(R) and renewal SS-cream(R), compared with those in pre-application and placebo groups (p<0.05). There was no significant difference in efficacy between SS-cream(R) and renewal SS-cream(R) groups (p>0.05). The mean BCRAP showed decreasing tendency following application of SS-cream(R) and renewal SS-cream(R); however, they were not significantly different (p>0.05). Both of original SS-cream(R) and renewal SS-cream(R) prolonged the BCRLT after their application to the glans penis in rabbits. The results indicate that they have local desensitizing effects on the sensory receptors of the dorsal nerve of the glans penis and may help control the ejaculatory reflex in patients with premature ejaculation.


Ejaculation; Reflex; Rabbits
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