Ann Dermatol.  2008 Jun;20(2):102-106. 10.5021/ad.2008.20.2.102.

Vancomycin-induced Linear IgA Bullous Dermatosis: A Case Report and Review of the Literature

• Kang MJ
• Kim HO
• Park YM

• KMID: 2172095
• DOI: http://doi.org/10.5021/ad.2008.20.2.102

Abstract

Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disease that can either occur without any apparent cause or be induced by the administration of certain drugs, the most common of which is vancomycin. We present a case of a 45-year-old woman who was diagnosed with vancomycin-induced LABD by the presence of a characteristic linear band of IgA along the basement membrane zone on direct immunofluorescence microscopy. Our patient showed complete recovery after a 2-week period during which vancomycin administration was discontinued.

Keyword

Linear IgA bullous dermatosis; Vancomycin

MeSH Terms

Basement Membrane
Female
Fluorescent Antibody Technique, Direct
Humans
Immunoglobulin A
Linear IgA Bullous Dermatosis
Microscopy
Middle Aged
Vancomycin
Immunoglobulin A
Vancomycin

Figure

• 

  Fig. 1 Pruritic, multiple, tense vesicles and confluent erythematous papules and plaques on the trunk (A, B), inguinal areas, and upper thighs (C). The Asboe-Hansen sign was negative on palpation (D).

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  Fig. 2 The biopsy specimen taken from a vesicle on the patient's trunk shows a subepidermal blister, filled with an inflammatory cell infiltrate consisting of neutrophils, a small number of lymphocytes, and eosinophils. Direct immunofluorescence microscopy of the specimen taken from perilesional normal skin demonstrates linear deposits of IgA along the basement membrane zone (H&E, A, C: ×100, B: ×400).

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