Ann Dermatol.  2010 Feb;22(1):106-109. 10.5021/ad.2010.22.1.106.

A Case of Neutrophilic Dermatosis of the Dorsal Hands with Concomitant Involvement of the Lips

Affiliations
  • 1Department of Dermatology, Inha University School of Medicine, Incheon, Korea. jshin@inha.ac.kr

Abstract

Neutrophilic dermatosis of the dorsal hands (NDDH) is a localized, pustular variant of acute febrile neutrophilic dermatosis (Sweet syndrome). The lesions of NDDH clinically resemble those of Sweet syndrome (SS), but they differ from classic SS according to their locations (NDDH is predominantly restricted to the dorsal hands) and the smaller number of accompanying systemic symptoms. The histology of the NDDH lesion shows a dense dermal neutrophilic infiltration. The lesions rapidly resolve after systemic corticosteroid and/or dapsone therapy. We herein report on a case of neutrophilic dermatosis of the dorsal hands in a 34-year-old woman. The patient also had skin changes with erythematous plaque on the right lips.

Keyword

Dorsal hand; Neutrophilic dermatosis; Sweet syndrome

MeSH Terms

Adult
Dapsone
Female
Hand
Humans
Lip
Neutrophils
Skin
Skin Diseases
Sweet Syndrome
Dapsone

Figure

  • Fig. 1 (A) Tender, erythematous, well-demarcated plaques on the dorsum of the right hand. (B) Erythematous plaque with small vesicles (arrow) on the right lips.

  • Fig. 2 The skin biopsy from the right hand shows prominent edema in the papillary dermis and a perivascular cellular infiltration that is mainly composed of neutrophils with no features of true vasculitis (A: H&E, ×40; B: H&E, ×200).

  • Fig. 3 The skin biopsy from the lips shows subepidermal separation and a perivascular and interstitial mixed-cell infiltrate composed of neutrophils and lymphocytes (A: H&E, ×40; B: H&E, ×200).


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Ann Dermatol. 2013;25(1):84-87.    doi: 10.5021/ad.2013.25.1.84.

Neutrophilic Dermatosis of the Palms in Association with Myelodysplastic Syndrome
Min-Young Yang, Jeong-Min Kim, Gun-Wook Kim, Margaret Song, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
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