Ann Dermatol.  2011 Aug;23(3):409-411. 10.5021/ad.2011.23.3.409.

Erythematous Granuloma Annulare

• Jang EJ
• Lee JY
• Kim MK
• Yoon TY

• KMID: 2171942
• DOI: http://doi.org/10.5021/ad.2011.23.3.409

Abstract

Granuloma annulare (GA) is a common, benign, chronic inflammatory disorder, which is characterized by grouped papules in an enlarging annular shape. It has been described in several clinical subtypes, including localized, generalized, subcutaneous, perforating, and erythematous types. Even though generalized, subcutaneous, and perforating types of GA are unusual, there are several reports of those types. However, erythematous or patch GA, has not been reported yet in the Korean literature. Herein, we report a 42-year-old woman with pruritic erythematous patches, which occurred on the extremities without preceding event, and showed typical clinical and histopatologic findings of erythematous GA.

Keyword

Erythema; Granuloma annulare; Patch

MeSH Terms

Adult
Erythema
Extremities
Female
Granuloma
Granuloma Annulare
Humans

Figure

• 

  Fig. 1 Round to oval erythematous patches on the left lower leg (A) and on the left forearm (B).

• 

  Fig. 2 (A) A moderate superficial and mid-dermal interstitial and perivascular infiltrate of mononuclear cells (H&E, ×40). (B) An interstitial infiltrate of lymphocytes and histiocytes, and mucin deposition between the collagen bundles (H&E, ×200). (C) Alcian blue pH 2.5 staining showed the deposition of increased bluish material between the degenerated collagen fibers (×100).

Reference

1. Muhlbauer JE. Granuloma annulare. J Am Acad Dermatol. 1980. 3:217–230.

2. Coelho R, Carvalho R, Rodrigues A, Afonso A, Cardoso J. Patch-type granuloma annulare. Eur J Dermatol. 2009. 19:285–286.

3. Prendiville JS. Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, editors. Granuloma annulare. Fitzpatrick's dermatology in general medicine. 2008. 7th ed. New York: McGraw-Hill;369–373.

4. Moyer DG. Papular granuloma annulare. Arch Dermatol. 1964. 89:41–45.

5. Stankler L, Leslie G. Generalized granuloma annulare. A report of a case and review of the literature. Arch Dermatol. 1967. 95:509–513.

6. Houcke-Bruge C, Delaporte E, Catteau B, Martin De Lassalle E, Piette F. Granuloma annulare following BCG vaccination. Ann Dermatol Venereol. 2001. 128:541–544.

7. Shideler SJ, Richards M. Granuloma annulare arising after herpes zoster. J Am Acad Dermatol. 1986. 15:1049–1050.

8. Sanli HE, Koçyiğit P, Arica E, Kurtyüksel M, Heper AO, Ozcan M. Granuloma annulare on herpes zoster scars in a Hodgkins disease patient following autologous peripheral stem cell transplantation. J Eur Acad Dermatol Venereol. 2006. 20:314–317.

9. Lim AC, Hart K, Murrell D. A granuloma annulare-like eruption associated with the use of amlodipine. Australas J Dermatol. 2002. 43:24–27.

10. Ogino A, Tamaki E. Atypical granuloma annulare. Transition from erythema to multiple type. Dermatologica. 1978. 156:97–100.

11. Gamo Villegas R, Sopena Barona J, Guerra Tapia A, Vergara Sanchez A, Rodríguez Peralto JL, Iglesias DIez L. Pustular generalized perforating granuloma annulare. Br J Dermatol. 2003. 149:866–868.

12. Morita K, Okamoto H, Miyachi Y. Papular elastolytic giant cell granuloma: a clinical variant of annular elastolytic giant cell granuloma or generalized granuloma annulare? Eur J Dermatol. 1999. 9:647–649.