Ann Dermatol.  2011 Dec;23(Suppl 3):S402-S403. 10.5021/ad.2011.23.S3.S402.

Fixed Drug Eruption Due to Allopurinol: Positive Oral Provocation

• Lee HJ
• Kim HS
• Park YM
• Kim HO
• Lee JY

• KMID: 2171883
• DOI: http://doi.org/10.5021/ad.2011.23.S3.S402

Abstract

A fixed drug eruption (FDE) is characterized by the presence of a solitary or multiple, pruritic, well-circumscribed, erythematous plaques. These lesions have tendency to recur at same sites and heal with residual hyperpigmenation. With repeated attacks, the size and/or number of the lesions may increase. So far, more than 100 drugs have been implicated in causing FDEs, including ibuprofen, sulfonamide, naproxen, and tetracylines. FDE caused by allopurinol has been rarely reported in the literature, but there has been no confirmed case based on oral provocation test. Herein, we report a case of FDE in which the lesions recurred whenever allopurinol was administered for the treatment of gout. A 64-year-old male experienced repeated episodes of well-demarcated dusky erythematous patches on the whole body for 2 months. He took allopurinol intermittently for amelioration of his gout symptom, but denied other medication history. Pruritic erythematous edema developed on the previous lesions 12 hours after oral provocation of 200 mg of allopurinol.

Keyword

Allopurinol; Fixed drug eruption; Oral provocation test; Topical provocation test

MeSH Terms

Allopurinol
Drug Eruptions
Edema
Gout
Humans
Ibuprofen
Male
Middle Aged
Naproxen
Allopurinol
Ibuprofen
Naproxen

Figure

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  Fig. 1 Clinical appearance of the fixed drug eruption on the patient's trunk (A) at the time of the 1st visit and (B) 12 hours after an oral provocation test with allopurinol.

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