Ann Dermatol.  2013 May;25(2):237-241. 10.5021/ad.2013.25.2.237.

Rapid Growing Superficial Cutaneous Leiomyosarcoma of the Face

• Lee KC
• Kim MS
• Choi H
• Na CH
• Shin BS

• KMID: 2171797
• DOI: http://doi.org/10.5021/ad.2013.25.2.237

Abstract

Leiomyosarcomas are uncommon malignant smooth muscle tumors, mainly derived from vessels or viscera. Superficial leiomyosarcomas are a rare soft tissue sarcoma arising from the dermis or subcutaneous tissue in the skin. According to tumor origin and location, they are divided into cutaneous and subcutaneous leiomyosarcoma. They have distinctly different histologic and prognostic features from each other. Superficial leiomyosarcomas show a predilection for the proximal extremities and tend to be slow growing. We report one rare case of superficial cutaneous leiomyosarcoma on the right temporal area of face, which showed an extremely rapid growing mass within 3 months.

Keyword

Face; Leiomyosarcoma; Skin

MeSH Terms

Dermis
Extremities
Leiomyosarcoma
Sarcoma
Skin
Smooth Muscle Tumor
Subcutaneous Tissue
Viscera

Figure

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  Fig. 1 Solitary 2×3 cm, well-demarcated, soft erythematous nodule with ulceration and bleeding on right temporal area of face.

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  Fig. 2 Histopathologic findings of the lesion revealed interlacing fascicles of spindle-shaped cells with varying degrees of intermingled collagen. Spindle cells had elongated blunt-ended nuclei with mitosis and hyperchromatic nuclei (H&E stain; A: ×100, B: ×200).

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  Fig. 3 Results of immunohistochemical staining showed a positive reaction of actin (A), vimentin (B), and desmin (C), and a negative reaction of CD-34 (D), epithelial membrane antigen (EMA) (E), cytokeratin (F), factor VIII (G), and S-100 (H) (A~H: ×100).

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  Fig. 4 Positron emission tomography-computed tomography showed a hypermetabolic lesion (arrow) on the right temporal area of the head.

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