Ann Dermatol.  2015 Oct;27(5):631-632. 10.5021/ad.2015.27.5.631.

Psoriatic Arthritis Complicating Systemic Sclerosis: Possible Involvement of M2 Macrophages

• Yamaoka T
• Inoue T
• Kitaba S
• Yokomi A
• Azukizawa
• Terao M
• Murota H
• Higashiyama M
• Katayama I

• KMID: 2171473
• DOI: http://doi.org/10.5021/ad.2015.27.5.631

Abstract

No abstract available.

MeSH Terms

Arthritis, Psoriatic*
Macrophages*
Scleroderma, Systemic*

Figure

• 

  Fig. 1 Clinical and histopathological manifestations in the patient. (A) Psoriatic skin lesion affecting the elbow. (B) Widespread skin thickening, progressing from the fingers to the trunk. (C) The skin biopsy specimen from the elbow has characteristics consistent with psoriasis (including parakeratosis), regular acanthosis, thinning of the suprapapillary plate, hypogranulosis, and mild superficial perivascular and interstitial infiltrates. (D) Biopsy specimen from the sclerotic lesional skin of the forearm. Thickened and homogeneous collagen bundles were visible (C, D: H&E, ×40). (E, F) Immunohistochemical staining for CD68 (macrophages). Each lesional skin sample had nearly equal positive CD68 levels in this dermis. (G, H) Immunohistochemical staining for CD163 (M2 macrophages). CD163-positive cells were increased in the lesional scleroderma (E~H: ×400).

Reference

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