Ann Dermatol.  2015 Oct;27(5):618-620. 10.5021/ad.2015.27.5.618.

CD56-Negative Extranodal NK/T-Cell Lymphoma, Nasal Type, with Extranasal Cutaneous Involvement

• Kim HJ
• Kim SH
• Oh SH

• KMID: 2171467
• DOI: http://doi.org/10.5021/ad.2015.27.5.618

Abstract

No abstract available.

MeSH Terms

Lymphoma*

Figure

• 

  Fig. 1 Clinical manifestation of the skin lesions. (A) A tender dark erythematous scaly indurated plaque with oozing on the right thigh. (B) A tender light brown, ill-defined induration with cigarette-paper-like fine scales on the right upper lateral arm.

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  Fig. 2 Microphotograph of the lesion on the right thigh. (A) Dense cellular infiltrates involving the deep dermis. Angiocentricity is conspicuous and epidermal necrosis is visible (H&E, ×12). (B) Atypical lymphocytes composed of small- to medium-sized cells with irregular folded nuclei, inconspicuous nucleoli, and moderate, pale to clear cytoplasm demonstrating angiocentric growth and angiodestruction. Frequent mitoses are seen (H&E, ×400). (C) Positive immunohistochemical staining with surface CD3 in atypical lymphoid cells (×400). (D) CD20 is not stained (×400). (E) CD56 is completely absent in the tumor (×400). (F) Epstein-Barr virus-encoded RNA in situ hybridization showing many positive cells (×400).

Reference

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