Ann Dermatol.  2015 Oct;27(5):485-491. 10.5021/ad.2015.27.5.485.

Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen Planus

• Kazancioglu HO
• Erisen M

• KMID: 2171447
• DOI: http://doi.org/10.5021/ad.2015.27.5.485

Abstract

BACKGROUND
The treatment options for oral lichen planus (OLP) are numerous and include topical and systemic agents. Intralesional and systemic corticosteroids are used; however, the therapeutic results are often disappointing.
OBJECTIVE
To compare the influence of ozone, laser, and topical corticosteroid therapies in the treatment of OLP.
METHODS
One hundred twenty adult patients with < or =3 cm atrophic-erosive biopsy-proven OLPs in the tongue or buccal mucosa were recruited into the study. They were randomly assigned, by preoperative envelope drawing, to be treated with low-level laser therapy (LLLT group), ozone therapy (ozonated group), and topical corticosteroid therapy (positive control group). A placebo treatment containing base ointment without the active corticosteroid component was administered to patients in the negative control group. Response rate scores were determined on the basis of changes in the appearance score and pain score of the lesions between baseline and after each treatment.
RESULTS
The study subjects consisted of 56 male and 64 female OLP patients with a combined mean age of 42.6+/-8.3 years (range, 28~55 years). No statistically significant difference was detected in clinical severity among the groups. The sign scores decreased in almost all scoring groups; however, statistically significant improvement was found in the ozonated and corticosteroid-treated groups. Symptom improvement was achieved after treatment with LLLT, ozone, and corticosteroid (p<0.05). The efficacy indices were significantly higher in the ozonated and corticosteroid-treated groups.
CONCLUSION
Ozone and corticosteroid therapies were more effective than 808-nm LLLT in the treatment of OLP.

Keyword

Dentistry; Lasers; Lichen planus; Pain; Ozone

MeSH Terms

Adrenal Cortex Hormones
Adult
Dentistry
Female
Humans
Low-Level Light Therapy*
Lichen Planus
Lichen Planus, Oral*
Male
Mouth Mucosa
Ozone*
Tongue
Adrenal Cortex Hormones
Ozone

Figure

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  Fig. 1 Ozone device and application probes.

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  Fig. 2 Application of ozone treatment.

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  Fig. 3 Mean sign scores of the groups at baseline and 1, 3, and 6 months after the end of treatments (Wilcoxon rank sum test: significant; p<0.05). LLLT: low-level laser therapy.

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  Fig. 4 Clinical view of the oral lichen planus lesion before treatment.

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  Fig. 5 Clinical view of the buccal lesion after seven sessions of ozone treatment.

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