Ann Dermatol.  2016 Apr;28(2):262-264. 10.5021/ad.2016.28.2.262.

A Case of Adult Generalized Cutaneous Langerhans Cell Histiocytosis

• Sun WG
• Zhong LS
• Chen H

• KMID: 2171393
• DOI: http://doi.org/10.5021/ad.2016.28.2.262

Abstract

No abstract available.

MeSH Terms

Adult*
Histiocytosis, Langerhans-Cell*
Humans

Figure

• 

  Fig. 1 (A~C) Multiple, erythematous, rust-colored papules and plaques with erosions distributed on the perianal area, groins, and axillae; (D~F) multiple, erythematous macules and papules on the face and ankle.

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  Fig. 2 (A) Under low-power microscopic examination, the lesion shows diffused infiltration of tumor cells in the dermis (H&E, ×25). (B) The lesion shows infiltration of large tumor cells in the dermis, and epidermotropism was appreciated (H&E, ×100). (C) The tumor cells have a moderate amount of eosinophilic cytoplasm and grooved nuclei consistent with Langerhans cells (H&E, ×400). Immunohistochemical analysis of the lesions shows tumor cells were diffusely positive for: (D) CD1a, (E) langerin, (F) S-100, and (G) CD4. (H) Ki-67 proliferating index is approximately 60% (D~H: ×100).

Reference

1. Singh A, Prieto VG, Czelusta A, McClain KL, Duvic M. Adult Langerhans cell histiocytosis limited to the skin. Dermatology. 2003; 207:157–161.

2. Holme SA, Mills CM. Adult primary cutaneous Langerhans' cell histiocytosis mimicking nodular prurigo. Clin Exp Dermatol. 2002; 27:250–251.

3. Aydogan K, Tunali S, Koran Karadogan S, Balaban Adim S, Turan H. Adult-onset Langerhans cell histiocytosis confined to the skin. J Eur Acad Dermatol Venereol. 2006; 20:890–892.

4. Furudate S, Fujimura T, Kambayashi Y, Kawano M, Ogasawara K, Tsukada A, et al. Successful treatment of adult onset Langerhans cell histiocytosis with bi-weekly administration of pegylated interferon-α. Acta Derm Venereol. 2014; 94:611–612.

5. Fernandes LB, Guerra JG, Costa MB, Paiva IG, Duran FP, Jacó DN. Langerhans cells histiocytosis with vulvar involvement and responding to thalidomide therapy--case report. An Bras Dermatol. 2011; 86:4 Suppl 1. S78–S81.