Infect Chemother.  2011 Feb;43(1):26-35. 10.3947/ic.2011.43.1.26.

Recent Advances in the Use of Anthelmintics for Treating Nematode Infections

• Chai JY

• KMID: 2170330
• DOI: http://doi.org/10.3947/ic.2011.43.1.26

Abstract

The recent trends of parasitic infections in Korea include remarkable decreases of soil-transmitted nematode infections and elimination of lymphatic filariasis. In comparison, enterobiasis (pinworm infection) continues to be prevalent among children and the cases of zoonotic tissue-invading nematode infection are slightly increasing or they are being increasingly diagnosed. In addition, imported parasitoses continue to be problems from the clinical and public health points of view. In this review, the advances in the management and anthelmintic treatment of these nematode infections are briefly reviewed. Albendazole, mebendazole, thiabendazole, flubendazole, pyrantel pamoate, pyrvinium pamoate, oxantel pamoate, levamisole, ivermectin, and diethylcarbamazine are the examples of anti-nematode anthelmintics that are currently being used. Although several of these drugs are known to be broad-spectrum anthelmintics, selection of each drug should be done specifically for each nematode infection, and with consideration of the specific conditions of each patient and the purposes, for example, when performing individual or mass treatment. It is hoped that the chemotherapy regimens reviewed here will help physicians to treat their patients infected with nematode parasites.

Keyword

Anthelmintics; Nematode; Albendazole; Mebendazole; Ivermectin; Diethycarbamazine

MeSH Terms

Albendazole
Anthelmintics
Child
Diethylcarbamazine
Elephantiasis, Filarial
Enterobiasis
Humans
Ivermectin
Korea
Levamisole
Mebendazole
Nematode Infections
Parasites
Public Health
Pyrantel Pamoate
Pyrvinium Compounds
Thiabendazole
Albendazole
Anthelmintics
Diethylcarbamazine
Ivermectin
Levamisole
Mebendazole
Pyrantel Pamoate
Pyrvinium Compounds
Thiabendazole

Reference

1. Chai JY. Recent trends of parasitic diseases in Korea. Infect Chemother. 2007. 39:Suppl 2. S156–S172.

2. Chai JY. Emerging parasitic diseases in Korea. J Korean Med Assoc. 2007. 50:946–958.

3. Keiser J, Utzinger J. The drugs we have and the drugs we need against major helminth infections. Adv Parasitol. 2010. 73:197–230.

4. Han ET, Guk SM, Kim JL, Jeong HJ, Kim SN, Chai JY. Detection of parasite eggs from archaeological excavations in the Republic of Korea. Mem Inst Oswaldo Cruz. 2003. 98:Suppl 1. 123–126.

5. Seo M, Guk SM, Kim J, Chai JY, Bok GD, Park SS, Oh CS, Kim MJ, Yil YS, Shin MH, Kang IU, Shin DH. Paleoparasitological report on the stool from a Medieval child mummy in Yangju, Korea. J Parasitol. 2007. 93:589–592.

6. Stryker EM. Extract from report for 1913, Suan Mine Hospital, Korea. China Med J. 1914. 28:277–280.

7. Ok KS, Kim YS, Song JH, Lee JH, Ryu SH, Lee JH, Moon JS, Whang DH, Lee HK. Trichuris trichiura infection diagnosed by colonoscopy: case reports and review of literature. Korean J Parasitol. 2009. 47:275–280.

8. Song HJ, Cho CH, Kim JS, Choi MH, Hong ST. Prevalence and risk factors for enterobiasis among preschool children in a metropolitan city in Korea. Parasitol Res. 2003. 91:46–50.

9. Park JH, Han ET, Kim WH, Shin EH, Guk SM, Kim JL, Chai JY. A survey of Enterobius vermicularis infection among children on western and southern coastal islands of the Republic of Korea. Korean J Parasitol. 2005. 43:129–134.

10. Chai JY, Hong ST. Chemotherapy of intestinal nematode infections. J Korean Soc Chemother. 1985. 3:119–129.

11. Keiser J, Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA. 2008. 299:1937–1948.

12. Adams VJ, Lombard CJ, Dhansay MA, Markus MB, Fincham JE. Efficacy of albendazole against the whipworm Tichuris trichiura-a randomised, controlled trial. S Afr Med J. 2004. 94:972–976.

13. Igual-Adell R, Oltra-Alcaraz C, Soler-Company E, Sánchez-Sánchez P, Matogo-Oyana J, Rodríguez-Calabuig D. Efficacy and safety of ivermectin and thiabendazole in the treatment of strongyloidiasis. Expert Opin Pharmacother. 2004. 5:2615–2619.

14. Chai JY. Korean Society of Infectious Diseases. Anthelmintics. Guidelines to Antibiotics. 2008. 3rd ed. Seoul: MIP;581–588.

15. Min DY, Ahn MH, Kim KM. Effect of flubendazole against Ascaris lumbricoides, Trichocephalus trichiurus and Enterobius vermicularis in infected children. Korean J Parasitol. 1986. 24:12–14.

16. Chai JY, Hong ST, Sohn WM, Lee SH. Anthelmintic effect of albendazole (Alzental@) on human intestinal nematodes. J Korean Soc Chemother. 1986. 4:86–88.

17. Park MS, Ahn YJ, Moon KR. Familial case of visceral larval migrans of Toxocara canis after ingestion of raw chicken liver. Korean J Pediatr Gastroenterol Nutr. 2010. 13:70–74.

18. Kim MH, Jung JW, Kwon JW, Kim TW, Kim SH, Cho SH, Min KU, Kim YY, Chang YS. A case of recurrent toxocariasis presenting with urticaria. Allergy Asthma Immunol Res. 2010. 2:267–270.

19. Kwon IH, Kim HS, Lee JH, Choi MH, Chai JY, Nakamura-Uchiyama F, Nawa Y, Cho KH. A serologically diagnosed human case of cutaneous larva migrans caused by Ancylostoma caninum. Korean J Parasitol. 2003. 41:233–237.

20. Chai JY. Proceedings of the 1st CME Seminar; Parasitic diseases of the gastrointestinal and biliary system. 1995. Korean Society of Gastroenterology;21–37.

21. Sohn WM, Kim HM, Chung DI, Yee ST, Yano A. The first human case of Trichinella spiralis infection in Korea. Korean J Parasitol. 2000. 38:111–115.

22. Choe G, Lee HS, Seo JK, Chai JY, Lee SH, Eom KS, Chi JG. Hepatic capillariasis: first case report in the Republic of Korea. Am J Trop Med Hyg. 1993. 48:610–625.

23. Kim MK, Kim CH, Yeom BW, Park SH, Choi SY, Choi JS. The first human case of hepatic dirofilariasis. J Korean Med Sci. 2002. 17:686–690.

24. Pampiglione S, Gustinelli A. Human hepatic capillariasis: a second case occurred in Korea. J Korean Med Sci. 2008. 23:560–561.

25. Lee SH, Hong ST, Chai JY, Kim WH, Kim YT, Song IS, Kim SW, Choi BI, Cross JH. A case of intestinal capillariasis in the Republic of Korea. Am J Trop Med Hyg. 1993. 48:542–546.

26. Hong ST, Kim YT, Choe G, Min YI, Cho SH, Kim JK, Kook J, Chai JY, Lee SH. Two cases of intestinal capillariasis in Korea. Korean J Parasitol. 1994. 32:43–48.

27. Lee NH, Sim YE, Kim CB, Yang YM, Lee SH, Lee CI, Kim DH, Hwang JW. Ten cases of eosinophilic meningitis. Eulji Med J. 1981. 4:143–151.

28. Lee SH, Hong ST, Chai JY. Description of a male Gnathostoma spinigerum recovered from a Thai woman with meningoencephalitis. Korean J Parasitol. 1988. 26:33–38.

29. Chai JY, Han ET, Shin EH, Park JH, Chu JP, Hirota M, Nakamura-Uchiyama F, Nawa Y. An outbreak of gnathostomiasis among Korean emigrants in Myanmar. Am J Trop Med Hyg. 2003. 69:67–73.

30. Jeong JW, Park JW, Kong HH, Chung DI, Kwak MS, Cho YW. A case of intraocular Thelasia callipaeda infestation. J Korean Ophthalmol Soc. 2006. 47:1517–1522.

31. World Health Organization. WHO model prescribing information: drugs used in parasitic diseases. 1995. 2nd ed. Geneva: WHO;1–146.

32. Rubinsky-Elefant G, Hirata CE, Yamamoto JH, Ferreira MU. Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms. Ann Trop Med Parasitol. 2010. 104:3–23.

33. Magnaval JF. Comparative efficacy of diethylcarbamazine and mebendazole for the treatment of human toxocariasis. Parasitology. 1995. 110:529–533.

34. Magnaval JF. Apparent weak efficacy of ivermectin for treatment of human toxocariasis. Antimicrob Agents Chemother. 1998. 42:2770.

35. Van den Enden E, Stevens A, Van Gompel A. Treatment of cutaneous larva migrans. N Engl J Med. 1998. 339:1246–1247.

36. Yap FB. Creeping eruption. Int J Infect Dis. 2010. 14:e545.

37. Moore DA, Girdwood RW, Chiodini PL. Treament of anisakiasis with albendazole. Lancet. 2002. 360:54.

38. Pacios E, Arias-Diaz J, Zuloaga J, Gonzalez-Armengol J, Villarroel P, Balibrea JL. Albendazole for the treatment of anisakiasis ileus. Clin Infect Dis. 2005. 41:1825–1826.

39. Dziekońska-Rynko J, Rokicki J, Jablonowski Z. Effects of ivermectin and albendazole against Anisakis simplex in vitro and in guinea pigs. J Parasitol. 2002. 88:395–398.

40. Manley KM, Embil JA. In vitro effect of ivermectin on Pseudoterranova decipiens survival. J Helminthol. 1989. 63:72–74.

41. Schellenberg RS, Tan BJ, Irvine JD, Stockdale DR, Gajadhar AA, Serhir B, Botha J, Armstrong CA, Woods SA, Blondeau JM, McNab TL. An outbreak of trichinellosis due to consumption of bear meat infected with Trichinella nativa, in 2 northern Saskatchewan communities. J Infect Dis. 2003. 188:835–843.

42. Kusolsuk T, Kamonrattanakun S, Wesanonthawech A, Dekumyoy P, Thaenkham U, Yoonuan T, Nuamtanong S, Sa-Nguankiat S, Pubampen S, Maipanich W, Panitchakit J, Marucci G, Pozio E, Waikagul J. The second outbreak of trichinellosis caused by Trichinella papuae in Thailand. Trans R Soc Trop Med Hyg. 2010. 104:433–437.

43. Berger T, Degrémont A, Gebbers JO, Tönz O. Hepatic capillariasis in a 1-year-old child. Eur J Pediatr. 1990. 149:333–336.

44. Rana SS, Bhasin DK, Bhatti HS, Gupta K, Gupta R, Nada R, Nagi B, Sinha SK, Singh K. Human intestinal capillariasis: diagnosis by jejunal fluid analysis obtained at enteroscopy and reversal of subtotal villous atrophy after treatment. Endoscopy. 2009. 41:Suppl 2. E102–E103.

45. Soukhathammavong P, Sayasone S, Harimanana AN, Akkhavong A, Thammasack S, Phoumindr N, Choumlivong K, Choumlivong K, Keoluangkhot V, Phongmany S, Akkhavong K, Hatz C, Strobel M, Odermatt P. Three cases of intestinal capillariasis in Lao People's Democratic Republic. Am J Trop Med Hyg. 2008. 79:735–738.

46. Wang X, Huang H, Dong Q, Lin Y, Wang Z, Li F, Nawa Y, Yoshimura K. A clinical study of eosinophilic meningoencephalitis caused by angiostrongyliasis. Chin Med J. 2002. 115:1312–1315.

47. Wang J, Qi H, Diao Z, Zheng X, Li X, Ma S, Ji A, Yin C. An outbreak of angiostrongyliasis cantonensis in Beijing. J Parasitol. 2010. 96:377–381.

48. Leone S, De Marco M, Ghirga P, Nicastri E, Esposito M, Narciso P. Eosinophilic meningitis in a returned traveler from Santo Domingo: case report and review. J Travel Med. 2007. 14:407–410.

49. Herman JS, Chiodini PL. Gnathostomiasis, another emerging imported disease. Clin Microbiol Rev. 2009. 22:484–492.

50. Rossi L, Rigano C, Tomio E, Frassetto D, Ferroglio E. Use of sustained-release moxidectin to prevent eyeworm (Thelazia callipaeda) infection in dogs. Vet Rec. 2007. 161:820–821.

51. Taylor MJ, Hoerauf A, Bockarie M. Lymphatic filariasis and onchocerciasis. Lancet. 2010. 376:1175–1185.

52. Cheun HI, Kong Y, Cho SH, Lee JS, Chai JY, Lee JS, Lee JK, Kim TS. Successful control of lymphatic filariasis in the Republic of Korea. Korean J Parasitol. 2009. 47:323–335.

53. McGarry HF, Pfarr K, Egerton G, Hoerauf A, Akue JP, Enyong P, Wanji S, Kläger SL, Bianco AE, Beeching NJ, Taylor MJ. Evidence against Wolbachia symbiosis in Loa loa. Filaria J. 2003. 2:9.

54. Simón F, Morchón R, González-Miguel J, Marcos-Atxutegi C, Siles-Lucas M. What is new about animal and human dirofilariosis? Trends Parasitol. 2009. 25:404–409.

55. Lee AC, Montgomery SP, Theis JH, Blagburn BL, Eberhard ML. Public health issues concerning the widespread distribution of canine heartworm disease. Trends Parasitol. 2010. 26:168–173.

56. Lee KJ, Park GM, Yong TS, Im K, Jung SH, Jeong NY, Lee WY, Yong SJ, Shin KC. The first Korean case of human pulmonary dirofilariasis. Yonsei Med J. 2000. 41:285–288.

57. Critchley J, Addiss D, Ejere H, Gamble C, Garner P, Gelband H. International Filariasis Review Group. Albendazole for the control and elimination of lymphatic filariasis: systematic review. Trop Med Int Health. 2005. 10:818–825.

58. Kamgno J, Pion SD, Tejiokem MC, Twum-Danso NA, Thylefors B, Boussinesq M. Randomized, controlled, double-blind trial with ivermectin on Loa loa microfilaraemia: efficacy of a low dose (approximately 25 microg/kg) versus current standard dose (150 microg/kg). Trans R Soc Trop Med Hyg. 2007. 101:777–785.

59. Kamgno J, Djomo PN, Pion SD, Thylefors B, Boussinesq M. A controlled trial to assess the effect of quinine, chloroquine, amodiaquine, and artesunate on Loa loa microfilaremia. Am J Trop Med Hyg. 2010. 82:379–385.

60. McCall JW, Genchi C, Kramer L, Guerrero J, Dzimianski MT, Supakorndej P, Mansour AM, McCall SD, Supakorndej N, Grandi G, Carson B. Heartworm and Wolbachia: therapeutic implications. Vet Parasitol. 2008. 158:204–214.