Clin Pediatr Hematol Oncol.  2015 Apr;22(1):1-7. 10.15264/cpho.2015.22.1.1.

Glucose-6-phosphate Dehydrogenase Deficiency

• Lee JM

• KMID: 2168913
• DOI: http://doi.org/10.15264/cpho.2015.22.1.1

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme disorder. There are more than 400 million people worldwide with G6PD deficiency, and its distribution is similar to that of malaria. G6PD deficiency is an X-linked recessive disorder. Most patients with G6PD deficiency may be asymptomatic throughout their lives. They may present as neonatal jaundice, or acute and chronic hemolysis. The most important point in the management of G6PD deficiency is to avoid oxidative stress. The prevalence of G6PD deficiency in Korea is about 0.9%. However, a nationwide survey has revealed that the number of patients with enzymopathy is increasing. Immigration of different ethnicities into Korea, and the rise of interracial marriages will likely lead to an increase in the number of patients with G6PD deficiency.

Keyword

Congenital nonspherocytic hemolytic anemia; Favism; G6PD deficiencies; Splenectomy; Neonatal jaundice; Congenital hemolytic anemia

MeSH Terms

Anemia, Hemolytic, Congenital
Anemia, Hemolytic, Congenital Nonspherocytic
Emigration and Immigration
Favism
Glucosephosphate Dehydrogenase
Glucosephosphate Dehydrogenase Deficiency*
Hemolysis
Humans
Infant, Newborn
Jaundice, Neonatal
Korea
Malaria
Marriage
Oxidative Stress
Prevalence
Splenectomy
Glucosephosphate Dehydrogenase