Clin Pediatr Hematol Oncol.  2016 Apr;23(1):61-64. 10.15264/cpho.2016.23.1.61.

A Case of Diffuse Neonatal Hemangiomatosis Successfully Treated with Propranolol

• Jeong SY
• Lee MJ
• Yu J

• KMID: 2168911
• DOI: http://doi.org/10.15264/cpho.2016.23.1.61

Abstract

We present a case of a 41-day-old girl with diffuse hemangiomatosis on her chin, right thigh, occipital area, and liver. She also had hepatomegaly, heart failure, and hypothyroidism. Hemangiomatosis did not respond to 2 weeks of oral administration of prednisolone, but was successfully treated with propranolol. After 2 years of propranolol treatment, the lesions of hemangiomatosis nearly disappeared. Hypothyroidism was controlled by levothyroxine replacement. As hemangiomatosis regressed, thyroid function was normalized. Propranolol may have adverse effects including hypotension, hypoglycemia, bronchoconstriction, and restlessness, but she did not experience such adverse effects. Propranolol could be the first choice for diffuse neonatal hemangiomatosis (DNH). Our case also suggests that thyroid function test is needed in patient with DNH.

Keyword

Diffuse neonatal hemangiomatosis; Propranolol; Liver hemangioma

MeSH Terms

Administration, Oral
Bronchoconstriction
Chin
Female
Heart Failure
Hepatomegaly
Humans
Hypoglycemia
Hypotension
Hypothyroidism
Liver
Prednisolone
Propranolol*
Psychomotor Agitation
Thigh
Thyroid Function Tests
Thyroid Gland
Thyroxine
Prednisolone
Propranolol
Thyroxine