J Bacteriol Virol.  2013 Jun;43(2):92-98. 10.4167/jbv.2013.43.2.92.

Nucleoside Diphosphate Kinase from Microorganisms

Affiliations
  • 1Department of Microbiology, School of Medicine, Chungnam National University, Daejeon, Korea. choich@cnu.ac.kr

Abstract

Nucleoside diphosphate kinase (Ndk) is ubiquitous and highly conserved multifunctional key enzyme in nucleotide metabolism. It generates nucleoside triphosphates (NTPs) by transfer of gamma-phosphates from nucleoside triphosphates such as ATP or GTP to nucleoside diphosphate. The formation of an autophosphorylated enzyme intermediate is involved in that mechanism. The phosphate is usually supplied by ATP and Ndk activity in different subcellular compartments. Ndk may regulate the crucial balance between ATP and GTP or other nucleoside triphosphates. Ndk is playing an important role in bacterial pathogenesis and emerging evidences recognize multiple roles of Ndk in host-microbe interaction. Here, I review some examples of the role of Ndk in intra- and extracellular microorganism.

Keyword

Nucleoside diphosphate kinase; Ndk; Extracellular ATP; Microorganism

MeSH Terms

Adenosine Triphosphate
Guanosine Triphosphate
Nucleoside-Diphosphate Kinase
Adenosine Triphosphate
Guanosine Triphosphate
Nucleoside-Diphosphate Kinase
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