Hanyang Med Rev.  2014 Nov;34(4):181-184. 10.7599/hmr.2014.34.4.181.

Genomics in Organ Transplantation

• Choi H
• Choi D
• Seo D

• KMID: 2168350
• DOI: http://doi.org/10.7599/hmr.2014.34.4.181

Abstract

The understanding of genetic diversities in humans by applying the state of the art genomic technologies has been accumulated and enriched since the last decades. Even in organ transplantation, these genomic technologies have not yet been widely applied and have less impact, except Human Leukocyte Antigen (HLA) matching. Pre- and post-operative care including surgical techniques in organ transplantation has improved reducing morbidity and mortality, but there are limitations and obstacles due to personal diversities coming from genetic variation. For this reason, the therapy combined with genomic information would be promising and beneficial in organ transplantation and would expect to give a new paradigm in personalized medicine in the near future. In this review, we introduce Next Generation Sequencing (NGS) technology and summarize potential benefits of these technologies in organ transplantation.

Keyword

Genomics; High-Thoughput Nucleotide Sequencing; Organ Transplantation; Graft Rejection

MeSH Terms

Genetic Variation
Genomics*
Graft Rejection
Humans
Leukocytes
Mortality
Organ Transplantation*
Transplants*
Precision Medicine

Figure

• 

  Fig. 1 Application of genomics in organ transplantation. Gathering samples are available in a point of time which are indicated by thick arrows.

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