Cancer Res Treat.  2012 Mar;44(1):63-68.

Five Cases Report of Solid Tumor Synchronously with Hematologic Malignancy

• Cui Y
• Liu T
• Zhou Y
• Ji Y
• Hou Y
• Jin W
• Feng Y

Abstract

The reported incidence of synchronous multiple primary cancer (SMPC) is rare, and it is even less common to observe synchronous solid tumor with a hematological malignancy. We report five cases of solid tumor presented synchronously with hematological malignancy, all observed within a 2 year period at the oncology department of a university hospital in Shanghai, China. These individual cases included lung adenocarcinoma with chronic myelogenous leukemia, colon cancer with solitary plasmocytoma, gastric adenocarcinoma with diffuse large B cell non-Hodgkin's lymphoma, lung adenocarcinoma with multiple myeloma, and colon cancer with diffuse large B cell non-Hodgkin's lymphoma. It is challenging to therapeutically control the biological behavior of concurrent multiple primary tumors, and there is no standard treatment for such rare conditions. In this paper we discuss these five cases of SMPC and their treatments.

Keyword

Synchronous multiple primary neoplasms; Solid neoplasms; Hematologic neoplasms

MeSH Terms

Adenocarcinoma
China
Colonic Neoplasms
Hematologic Neoplasms
Incidence
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lung
Lung Neoplasms
Lymphoma, Non-Hodgkin
Multiple Myeloma
Neoplasms, Multiple Primary
Plasmacytoma
Adenocarcinoma
Lung Neoplasms

Figure

• 

  Fig. 1 Case 3 pathological figures. (A) Post surgery colon adenocarcinoma (H&E staining, ×40). (B) Biopsy result revealing lymphoma (H&E staining, ×40).

• 

  Fig. 2 Case 4 pathological figures. (A) Computed tomography scan result identifying liver metastasis from colon cancer. (B) Computed tomography scan identifying lung metastasis from colon cancer. (C) Colon adenocarcinoma revealed by colonoscopy (H&E staining, ×10). (D) Bone marrow aspiration smear showing dysplastic plasma cells (Giemsa staining, ×10).

• 

  Fig. 3 Case 5 pathological figures. (A) biopsy result revealing lymphoma in right upper abdominal mass (H&E staining, ×40). (B) Gastric adenocarcinoma identified after radical subtotal gastrectomy (H&E staining, ×40). F18-FDG high uptake lesion at gastric sinus (C) and right upper abdomen (D), as observed by positron emission tomography/computed tomography).

Reference

1. Johnson C. SEER program coding and staging manual 2004. NIH publication no. 04-5581. 2004. 4th ed. Bethesda, MD: National Cancer Institute.

2. Fraumeni JF Jr, Curtis RE, Edwards BK, Tucker MA. Curtis RE, Freedman DM, Ron E, Ries LA, Hacker DG, Edwards BK, editors. Introduction. New malignancies among cancer survivors: SEER Cancer Registries, 1973-2000. 2006. Bethesda, MD: National Cancer Institute.

3. Annunziata M, Celentano M, Pocali B, D'Amico MR, Palmieri S, Viola A, et al. Vinorelbine plus intermediate dose cyclophosphamide is an effective and safe regimen for the mobilization of peripheral blood stem cells in patients with multiple myeloma. Ann Hematol. 2006; 85:394–399. PMID: 16538502.

4. Ramirez JM, Ocio EM, San Miguel JF, Pandiella A. Pemetrexed acts as an antimyeloma agent by provoking cell cycle blockade and apoptosis. Leukemia. 2007; 21:797–804. PMID: 17315026.

5. Habuchi T. Origin of multifocal carcinomas of the bladder and upper urinary tract: molecular analysis and clinical implications. Int J Urol. 2005; 12:709–716. PMID: 16174043.

6. Tabor MP, Brakenhoff RH, Ruijter-Schippers HJ, Van Der Wal JE, Snow GB, Leemans CR, et al. Multiple head and neck tumors frequently originate from a single preneoplastic lesion. Am J Pathol. 2002; 161:1051–1060. PMID: 12213734.

7. Horii A, Han HJ, Shimada M, Yanagisawa A, Kato Y, Ohta H, et al. Frequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers. Cancer Res. 1994; 54:3373–3375. PMID: 8012952.

8. Ares SL, Polo S, Ezcurdia L, Tognelli F, Mussini S, Gercovich N, et al. Multiple primary cancer in adults (MPCA). J Clin Oncol. 2006; 24(18S):16027.

9. Demandante CG, Troyer DA, Miles TP. Multiple primary malignant neoplasms: case report and a comprehensive review of the literature. Am J Clin Oncol. 2003; 26:79–83. PMID: 12576929.

10. Wotherspoon AC, Isaacson PG. Synchronous adenocarcinoma and low grade B-cell lymphoma of mucosa associated lymphoid tissue (MALT) of the stomach. Histopathology. 1995; 27:325–331. PMID: 8847062.

11. Lovell MO, Valente PT. Unique collision of hodgkin lymphoma and adenosquamous carcinoma in the uterine cervix: synchronous malignant neoplasms of the cervix. J Low Genit Tract Dis. 2003; 7:307–310. PMID: 17051090.

12. Wronski M, Ziarkiewicz-Wroblewska B, Gornicka B, Cebulski W, Slodkowski M, Wasiutynski A, et al. Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms. World J Gastroenterol. 2006; 12:5360–5362. PMID: 16981268.

13. Tamura M, Shinagawa M, Funaki Y. Synchronous triple early cancers occurring in the stomach, colon and gallbladder. Asian J Surg. 2003; 26:46–48. PMID: 12527496.

14. Van Dalen R, Church J, McGannon E, Fay S, Burke C, Clark B. Patterns of surgery in patients belonging to amsterdam-positive families. Dis Colon Rectum. 2003; 46:617–620. PMID: 12792437.