Clin Exp Otorhinolaryngol.  2011 Mar;4(1):1-10.

Current Management of Advanced Resectable Oral Cavity Squamous Cell Carcinoma

• Ow TJ
• Myers JN

Abstract

The oral cavity is the most common site of head and neck squamous cell carcinoma, a disease which results in significant morbidity and mortality worldwide. Though the primary modality of treatment for patients with oral cavity cancer remains surgical resection, many patients present with advanced disease and are thus treated using a multi-disciplinary approach. Patients with extracapsular spread of lymphatic metastasis and surgical margins that remain positive have been found to be at high risk for local-regional recurrence and death from disease, and are most often recommended to receive both post-operative radiation as well as systemic chemotherapy. The basis for this approach, as well as scientific developments that underly future trials of novels treatments for patients with high-risk oral cavity cancer are reviewed.

Keyword

Oral cancer; Head and neck neoplasms; Treatment; Surgery; Radiotherapy; Chemotherapy

MeSH Terms

Carcinoma, Squamous Cell
Head
Head and Neck Neoplasms
Humans
Lymphatic Metastasis
Mouth
Mouth Neoplasms
Neck
Recurrence

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