Clin Exp Otorhinolaryngol.  2016 Mar;9(1):80-84. 10.21053/ceo.2016.9.1.80.

Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series

• Santos RS
• Andrade MF
• Alves FD
• Kowalski L
• Perez DE

• KMID: 2166294
• DOI: http://doi.org/10.21053/ceo.2016.9.1.80

Abstract

OBJECTIVES
Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution.
METHODS
Clinical data were obtained from the medical records. All cases were histologically reviewed to confirm the diagnosis, and immunohistochemical reactions were performed in the cases submitted to biopsy.
RESULTS
All patients were males and the mean age was 40.5 years old. The sites of the metastatic tumors were gingival mucosa, floor of the mouth, oropharynx, and larynx. Two tumors appeared as submucosal nodules with normal color; one lesion was a blackish nodular lesion, and one was shown to be an ulcerated lesion. The size of tumors ranged from 2.0 to 4.0 cm. All patients had developed systemic disease at time of diagnosis of metastatic tumor in the head and neck mucosa. Survival rates ranged from 2 to 19 months after the diagnosis of the metastatic mucosal melanoma in the head and neck region.
CONCLUSION
Although rare, patients with melanoma must be closely and regularly followed up, with careful routine examination of head and neck, because metastatic tumors in this region seem to be part of a lethal widespread metastatic disease.

Keyword

Head and Neck Neoplasms; Melanoma; Mouth; Mucous Membrane; Neoplasm Metastasis

MeSH Terms

Biopsy
Diagnosis
Head and Neck Neoplasms
Head*
Humans
Larynx
Male
Medical Records
Melanoma*
Mouth
Mucous Membrane*
Neck*
Neoplasm Metastasis*
Oropharynx
Survival Rate
Ulcer

Figure

• 

  Fig. 1. Case 2 appearing as a blackish submucosal nodule located on the oropharynx.

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  Fig. 2. Case 1: Spindle and epithelioid malignant cells adjacent to intact and atrophic squamous epithelium that recovered the oral mucosa. Melanin was not observed (H&E, ×200).

• 

  Fig. 3. (A) Case 4: Tumor cells showing strong positivity for S-100 protein (immunohistochemistry, ×400). (B) Case 3: Pleomorphic malignant cells presenting cytoplasmic positivity for HMB45 (immunohistochemistry, ×400).

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