Genomics Inform.  2006 Jun;4(2):87-93.

Improved Algorithms for the Identification of Yeast Proteins and Significant Transcription Factor and Motif Analysis

• Lee SW
• Hong SE
• Lee KY
• Choi DI
• Chung HY
• Hur CG

Abstract

With the rapid development of MS technologiesy, the demands for a more sophisticated MS interpretation algorithm haves grown as well. We have developed a new protein fingerprinting method using a binomial distribution, (fBIND). With the fBIND, we improved the performance accuracy of protein fingerprinting up to the maximum 49% (more than MOWSE) and 2% than(at a previous binomial distribution approach studied by of Wool et al.) as compared to the established algorithms. Moreover, we also suggest a the statistical approach to define the significance of transcription factors and motifs in the identified proteins based on the Gene Ontology (GO).

Keyword

peptide mass fingerprinting; molecular weight search; binomial distribution; hypergeometric distribution

MeSH Terms

Binomial Distribution
Fungal Proteins*
Gene Ontology
Peptide Mapping
Transcription Factors*
Wool
Yeasts*
Fungal Proteins
Transcription Factors