Cancer Res Treat.  2010 Mar;42(1):53-56.

A Case of Synchronous Double Primary Cancer of the Penis and Urinary Bladder

• Cho YS
• Lee JA
• Kim SB
• Gong SJ
• Kim JH
• Youn SM
• Kim ET

Abstract

Multiple primary cancers are the occurrence of more than two cancers of different origin in an individual. Penile cancer is a rare disease, and finding it combined with other cancers is even rarer. A 64-year-old man with a painful penile mass was referred to us from a primary urological clinic. We performed a biopsy of the penile mass and the histology revealed a well-differentiated squamous cell carcinoma. Abdominal computed tomography showed a localized bladder tumor with inguinal lymphadenopathy. The patient underwent a partial penectomy, transurethral resection of the bladder tumor and inguinal lymph node dissection. The histology of the bladder tumor was high-grade papillary carcinoma, and that of the lymph node was squamous cell carcinoma. The penile and bladder tumors were in stage II (T1N1M0) and stage I (T1N0M0), respectively. We successfully treated the patient with adjuvant radiotherapy and systemic chemotherapy.

Keyword

Neoplasms; Multiple primary; Urinary bladder neoplasms; Penile neoplasms

MeSH Terms

Biopsy
Carcinoma, Papillary
Carcinoma, Squamous Cell
Humans
Lymph Node Excision
Lymph Nodes
Lymphatic Diseases
Male
Middle Aged
Penile Neoplasms
Radiotherapy, Adjuvant
Rare Diseases
Urinary Bladder
Urinary Bladder Neoplasms

Figure

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  Fig. 1 The pathologic features of the penile tumor (H&E stain, ×200). The microphotograph showed an invasive squamous cell carcinoma with well-differentiated mature squamous cells and abundant keratin pearls and occasional well-developed intercellular bridges.

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  Fig. 2 (A) The abdominal CT showed an approximately 1 cm sized enhancing luminal protruding polypoid mass on the left posterior wall of the urinary bladder. (B) The abdominal CT showed a 2.2 cm enlarged lymph node with a tendency for focal infiltration in the left inguinal area.

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  Fig. 3 (A) The pathologic features of the bladder tumor (H&E stain, ×200). The microphotograph showed an invasive urothelial carcinoma with more nuclear pleomorphism, anaplasia and many mitotic figures. (B) The pathologic features of the left inguinal lymph node (H&E stain, ×100). The microphotograph showed a metastatic squamous cell carcinoma with less differentiation and more nuclear pleomorphism and mitotic activity.

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