Clin Endosc.  2013 Sep;46(5):576-578.

Successful Endoscopic Mucosal Resection of a Low Esophageal Carcinoid Tumor

Affiliations
  • 1Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. parksj6406@yahoo.co.kr

Abstract

Esophageal carcinoid tumors remain some of the rarest of all carcinoid tumors, with only several cases previously reported in the literature. The endoscopic mucosal resection of selected carcinoid tumors has been shown to be a valid, safe, and effective method of treatment. Endoscopic ultrasonography is the technique of choice to select patients eligible for endoscopic resection. Here, we report successful endoscopic mucosal resection of a low esophageal carcinoid tumor and review the relevant literature. The present case is the first reported case of esophageal carcinoid tumor in Korea.

Keyword

Esophageal carcinoid tumor; Endosonography; Endoscopic mucosal resection

MeSH Terms

Carcinoid Tumor
Endosonography
Humans
Korea

Figure

  • Fig. 1 Endoscopic view of the lesion. An 0.8×0.5-cm, ovoid, elevated, submucosal esophageal lesion was noted 35 cm from the upper incisors.

  • Fig. 2 Endoscopic ultrasound image of the lesion. Endoscopic ultrasonography shows homogenous, hypoechoic lesion within the mucosal layer.

  • Fig. 3 The specimen after endoscopic mucosal resection.

  • Fig. 4 Histologic examination of the resected specimen. The tumor was located in the mucosal layer, and overlying normal squamous epithelium was seen. The tumor consisted of round cells arranged in sheets (H&E stain, ×100).

  • Fig. 5 Immunohistochemical of examination the resected specimen (×200). The tumor cells show positive reaction for synaptophysin.


Reference

1. Brenner S, Heimlich H, Widman M. Carcinoid of esophagus. N Y State J Med. 1969; 69:1337–1339. PMID: 5255420.
2. Tateishi R, Taniguchi H, Wada A, Horai T, Taniguchi K. Argyrophil cells and melanocytes in esophageal mucosa. Arch Pathol. 1974; 98:87–89. PMID: 4134908.
3. Capella C, Solcia E, Sobin LH, Arnold R. Endocrine tumours of the oesophagus. In : Hamilton SR, Aaltonen LA, editors. Pathology and Gen etics of Tumours of the Digestive System. Lyon: International Agency for Research on Cancer;2000. p. 26–27.
4. Modlin IM, Sandor A. An analysis of 8305 cases of carcinoid tumors. Cancer. 1997; 79:813–829. PMID: 9024720.
Article
5. Modlin IM, Shapiro MD, Kidd M. An analysis of rare carcinoid tumors: clarifying these clinical conundrums. World J Surg. 2005; 29:92–101. PMID: 15599742.
Article
6. Lindberg GM, Molberg KH, Vuitch MF, Albores-Saavedra J. Atypical carcinoid of the esophagus: a case report and review of the literature. Cancer. 1997; 79:1476–1481. PMID: 9118026.
7. Broicher K, Hienz HA. Carcinoid syndrome in primary esophageal tu mor. Z Gastroenterol. 1974; 12(Suppl):377–384. PMID: 4418379.
8. Klöppel G, Rindi G, Anlauf M, Perren A, Komminoth P. Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors. Virchows Arch. 2007; 451(Suppl 1):S9–S27. PMID: 17684761.
Article
9. Kulke MH, Benson AB 3rd, Bergsland E, et al. Neuroendocrine tumors. J Natl Compr Canc Netw. 2012; 10:724–764. PMID: 22679117.
10. Chong FK, Graham JH, Madoff IM. Mucin-producing carcinoid ("composite tumor") of upper third of esophagus: a variant of carcinoid tu mor. Cancer. 1979; 44:1853–1859. PMID: 227580.
11. Younghusband JD, Aluwihare AP. Carcinoma of the oesophagus: factors influencing survival. Br J Surg. 1970; 57:422–430. PMID: 5431572.
Article
12. Ahmad NA, Kochman ML, Long WB, Furth EE, Ginsberg GG. Efficacy, safety, and clinical outcomes of endoscopic mucosal resection: a study of 101 cases. Gastrointest Endosc. 2002; 55:390–396. PMID: 11868015.
Article
13. Mashimo Y, Matsuda T, Uraoka T, et al. Endoscopic submucosal resection with a ligation device is an effective and safe treatment for carcino id tumors in the lower rectum. J Gastroenterol Hepatol. 2008; 23:218–221. PMID: 18289355.
14. Akasu T, Moriya Y, Sugihara K. Transrectal ultrasonography of a small rectal carcinoid tumor with lymph node metastasis: a case report. Jpn J Clin Oncol. 1996; 26:112–115. PMID: 8609694.
Article
15. Varas Lorenzo MJ, Miquel Collell JM, Maluenda Colomer MD, Boix Valverde J, Armengol Miro JR. Preoperative detection of gastrointestinal neuroendocrine tumors using endoscopic ultrasonography. Rev Esp Enferm Dig. 2006; 98:828–836. PMID: 17198475.
Article
Full Text Links
  • CE
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr