Brain Neurorehabil.  2015 Sep;8(2):73-80. 10.12786/bn.2015.8.2.73.

Sleep Disorders after Stroke

Affiliations
  • 1Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Korea. dykimsmart@gmail.com

Abstract

Sleep-disordered breathing (SDB) and sleep-wake disorders (SWD) are frequent after stroke. Not only brain damage per se but also the consequences of stroke (immobilization, pain, hypoxia, depression etc) affect sleep wake cycle and breathing control. SDB and SWDs have a negative effect on rehabilitation outcome and quality of life after stroke. A high suspicion may lead to a diagnosis and subsequent treatment of sleep disorders after stroke and contribute to rehabilitation of these patients. This article summarizes the knowledge about the role of SDB and SWD after stroke, reviewing clinical characteristics, clinical outcome after stroke, diagnosis and treatment of various sleep disturbances.

Keyword

stroke; sleep-disordered breathing; sleep-wake disorders; rehabilitation; outcome; risk factors

MeSH Terms

Anoxia
Brain
Depression
Diagnosis
Humans
Quality of Life
Rehabilitation
Respiration
Risk Factors
Sleep Apnea Syndromes
Sleep Wake Disorders*
Stroke*
Treatment Outcome

Figure

  • Fig. 1 Sleep diary.


Reference

1. Gasanov RL, Gitlevich TR, Lesnyak VN, Levin Ya I. Structure of nocturnal sleep in patients with cerebral insult. Neurosci Behav Physiol. 1998; 28:325–329.
2. Bassetti CL. Sleep and stroke. Semin Neurol. 2005; 25:19–32.
3. Bakken LN, Lee KA, Kim HS, Finset A, Lerdal A. Sleep-Wake Patterns during the Acute Phase after First-Ever Stroke. Stroke Res Treat. 2011; 2011:936298.
4. Giubilei F, Iannilli M, Vitale A, Pierallini A, Sacchetti ML, Antonini G, et al. Sleep patterns in acute ischemic stroke. Acta Neurol Scand. 1992; 86:567–571.
5. Bassetti CL, Aldrich MS. Sleep electroencephalogram changes in acute hemispheric stroke. Sleep Med. 2001; 2:185–194.
6. Djonlagic I, Saboisky J, Carusona A, Stickgold R, Malhotra A. Increased sleep fragmentation leads to impaired off-line consolidation of motor memories in humans. PLoS One. 2012; 7:e34106.
7. Siengsukon CF, Boyd LA. Sleep enhances implicit motor skill learning in individuals poststroke. Top Stroke Rehabil. 2008; 15:1–12.
8. Gao B, Kilic E, Baumann CR, Hermann DM, Bassetti CL. Gamma-hydroxybutyrate accelerates functional recovery after focal cerebral ischemia. Cerebrovasc Dis. 2008; 26:413–419.
Article
9. Charles MS, Zhang JH. Sleep a therapeutic target for stroke. Exp Neurol. 2012; 234:1–4.
Article
10. Bassetti CL, Milanova M, Gugger M. Sleep-disordered breathing and acute ischemic stroke: diagnosis, risk factors, treatment, evolution, and long-term clinical outcome. Stroke. 2006; 37:967–972.
Article
11. Dziewas R, Humpert M, Hopmann B, Kloska SP, Ludemann P, Ritter M, et al. Increased prevalence of sleep apnea in patients with recurring ischemic stroke compared with first stroke victims. J Neurol. 2005; 252:1394–1398.
Article
12. Parra O, Arboix A, Bechich S, Garcia-Eroles L, Montserrat JM, Lopez JA, et al. Time course of sleep-related breathing disorders in first-ever stroke or transient ischemic attack. Am J Respir Crit Care Med. 2000; 161:375–380.
Article
13. Nopmaneejumruslers C, Kaneko Y, Hajek V, Zivanovic V, Bradley TD. Cheyne-Stokes respiration in stroke: relationship to hypocapnia and occult cardiac dysfunction. Am J Respir Crit Care Med. 2005; 171:1048–1052.
14. Hermann DM, Siccoli M, Kirov P, Gugger M, Bassetti CL. Central periodic breathing during sleep in acute ischemic stroke. Stroke. 2007; 38:1082–1084.
Article
15. Rola R, Wierzbicka A, Wichniak A, Jernajczyk W, Richter P, Ryglewicz D. Sleep related breathing disorders in patients with ischemic stroke and transient ischemic attacks: respiratory and clinical correlations. J Physiol Pharmacol. 2007; 58:Suppl 5. 575–582.
16. Siccoli MM, Valko PO, Hermann DM, Bassetti CL. Central periodic breathing during sleep in 74 patients with acute ischemic stroke - neurogenic and cardiogenic factors. J Neurol. 2008; 255:1687–1692.
Article
17. Martinez-Garcia MA, Galiano-Blancart R, Soler-Cataluna JJ, Cabero-Salt L, Roman-Sanchez P. Improvement in nocturnal disordered breathing after first-ever ischemic stroke: role of dysphagia. Chest. 2006; 129:238–245.
Article
18. Winward C, Sackley C, Metha Z, Rothwell PM. A population-based study of the prevalence of fatigue after transient ischemic attack and minor stroke. Stroke. 2009; 40:757–761.
Article
19. Hermann DM, Siccoli M, Brugger P, Wachter K, Mathis J, Achermann P, et al. Evolution of neurological, neuropsychological and sleepwake disturbances after paramedian thalamic stroke. Stroke. 2008; 39:62–68.
Article
20. Leppavuori A, Pohjasvaara T, Vataja R, Kaste M, Erkinjuntti T. Insomnia in ischemic stroke patients. Cerebrovasc Dis. 2002; 14:90–97.
Article
21. Autret A, Lucas B, Mondon K, Hommet C, Corcia P, Saudeau D, et al. Sleep and brain lesions: a critical review of the literature and additional new cases. Neurophysiol Clin. 2001; 31:356–375.
Article
22. Lee SJ, Kim JS, Song IU, An JY, Kim YI, Lee KS. Poststroke restless legs syndrome and lesion location: anatomical considerations. Mov Disord. 2009; 24:77–84.
Article
23. Culebras A, Moore JT. Magnetic resonance findings in REM sleep behavior disorder. Neurology. 1989; 39:1519–1523.
Article
24. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005; 353:2034–2041.
Article
25. Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med. 2005; 172:1447–1451.
Article
26. Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI. Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep. 2009; 32:447–470.
Article
27. Faccenda JF, Mackay TW, Boon NA, Douglas NJ. Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndrome. Am J Respir Crit Care Med. 2001; 163:344–348.
Article
28. Davies DP, Rodgers H, Walshaw D, James OF, Gibson GJ. Snoring, daytime sleepiness and stroke: a case-control study of first-ever stroke. J Sleep Res. 2003; 12:313–318.
Article
29. Pennestri MH, Montplaisir J, Colombo R, Lavigne G, Lanfranchi PA. Nocturnal blood pressure changes in patients with restless legs syndrome. Neurology. 2007; 68:1213–1218.
Article
30. Turkington PM, Allgar V, Bamford J, Wanklyn P, Elliott MW. Effect of upper airway obstruction in acute stroke on functional outcome at 6 months. Thorax. 2004; 59:367–371.
Article
31. Sahlin C, Sandberg O, Gustafson Y, Bucht G, Carlberg B, Stenlund H, et al. Obstructive sleep apnea is a risk factor for death in patients with stroke: a 10-year follow-up. Arch Intern Med. 2008; 168:297–301.
Article
32. Hublin C, Partinen M, Koskenvuo M, Kaprio J. Sleep and mortality: a population-based 22-year follow-up study. Sleep. 2007; 30:1245–1253.
Article
33. Vgontzas AN, Liao D, Bixler EO, Chrousos GP, Vela-Bueno A. Insomnia with objective short sleep duration is associated with a high risk for hypertension. Sleep. 2009; 32:491–497.
Article
34. Mallon L, Broman JE, Hetta J. Restless legs symptoms with sleepiness in relation to mortality: 20-year follow-up study of a middle-aged Swedish population. Psychiatry Clin Neurosci. 2008; 62:457–463.
Article
35. Palombini L, Guilleminault C. Stroke and treatment with nasal CPAP. Eur J Neurol. 2006; 13:198–200.
Article
36. Martinez-Garcia MA, Soler-Cataluna JJ, Ejarque-Martinez L, Soriano Y, Roman-Sanchez P, Illa FB, et al. Continuous positive airway pressure treatment reduces mortality in patients with ischemic stroke and obstructive sleep apnea: a 5-year follow-up study. Am J Respir Crit Care Med. 2009; 180:36–41.
Article
37. Lazar RM, Fitzsimmons BF, Marshall RS, Berman MF, Bustillo MA, Young WL, et al. Reemergence of stroke deficits with midazolam challenge. Stroke. 2002; 33:283–285.
Article
38. Palomaki H, Berg A, Meririnne E, Kaste M, Lonnqvist R, Lehtihalmes M, et al. Complaints of poststroke insomnia and its treatment with mianserin. Cerebrovasc Dis. 2003; 15:56–62.
Article
39. Anderson SL, Vande Griend JP. Quetiapine for insomnia: A review of the literature. Am J Health Syst Pharm. 2014; 71:394–402.
Article
40. National Heart, Lung, and Blood Institute Working Group on Insomnia. Insomnia: assessment and management in primary care. National Heart, Lung, and Blood Institute Working Group on Insomnia. Am Fam Physician. 1999; 59:3029–3303.
41. Thaxton L, Myers MA. Sleep disturbances and their management in patients with brain injury. J Head Trauma Rehabil. 2002; 17:335–348.
Article
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