J Bone Metab.  2016 May;23(2):51-54. 10.11005/jbm.2016.23.2.51.

Can Alarming Improve Compliance with Weekly Bisphosphonate in Patients with Osteoporosis?

• Nho JH
• Lee YK
• Ha YC
• Kim CH
• Suh YS
• Koo KH

• KMID: 2165118
• DOI: http://doi.org/10.11005/jbm.2016.23.2.51

Abstract

BACKGROUND
Although bisphosphonate is effective for the prevention and treatment of osteoporosis, poor medication compliance is a key-limiting factor. We determined whether alarm clock could improve compliance with weekly bisphosphonate in patients with osteoporosis, by comparing with age- and gender-matched control group.
METHODS
Fifty patients with osteoporosis were recruited and participated in alarm clock group. Patients were asked to take orally weekly risedronate for 1 year, and received alarm clock to inform the time of taking oral bisphosphonate weekly. Using the propensity score matching with age and gender, 50 patients were identified from patients with osteoporosis medication. We compared the compliance with bisphosphonate using medication possession ratio (MPR) between two groups.
RESULTS
Although there was no significant difference of baseline characteristics between both groups, the mean MPR (0.80±0.33) of alarm clock group was higher than that (0.56±0.34) of control group (P<0.001).
CONCLUSIONS
Alarming could improve the compliance with weekly oral bisphosphonate in patients with osteoporosis.

Keyword

Bisphosphonate osteoporosis; Patient compliance

MeSH Terms

Compliance*
Humans
Medication Adherence
Osteoporosis*
Patient Compliance
Propensity Score
Risedronate Sodium
Risedronate Sodium