Allergy Asthma Respir Dis.  2016 May;4(3):221-224. 10.4168/aard.2016.4.3.221.

Toxic epidermal necrolysis induced by deflazacort

• Youn D
• Kim MH
• Koh SW
• Kim JW
• Yoon SE
• Jeon HK
• Cho YJ

• KMID: 2165086
• DOI: http://doi.org/10.4168/aard.2016.4.3.221

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions to drugs, which carry significant morbidities and mortalities. Although SJS and TEN can be treated by corticosteroids or intravenous immunoglobulin, they may be induced by steroids. We experienced a 36-year-old man who developed whole body erythromatous maculopapular rashes and multiple bullae after ingestion of deflazacort. After avoidance of deflazacort and use of dexamethasone, skin lesions resorbed. We reported a case of TEN diagnosed by characteristic clinical findings with a brief review of the literature.

Keyword

Stevens-Johnson syndrome; Nephrotic syndrome; Drug hypersensitivity syndrome

MeSH Terms

Adrenal Cortex Hormones
Adult
Dexamethasone
Drug Hypersensitivity Syndrome
Eating
Exanthema
Humans
Immunoglobulins
Mortality
Nephrotic Syndrome
Skin
Steroids
Stevens-Johnson Syndrome*
Adrenal Cortex Hormones
Dexamethasone
Immunoglobulins
Steroids

Figure

• 

  Fig. 1 Patient's whole body showed erythromatous maculopapular rash and multiple bullae at admission.

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