J Vet Sci.  2015 Jun;16(2):237-240. 10.4142/jvs.2015.16.2.237.

Pathogenicity of H5N8 virus in chickens from Korea in 2014

• Song BM
• Kang HM
• Lee EK
• Jeong J
• Kang Y
• Lee HS
• Lee YJ

• KMID: 2164535
• DOI: http://doi.org/10.4142/jvs.2015.16.2.237

Abstract

In 2014, two genetically distinct H5N8 highly pathogenic avian influenza (HPAI) viruses were isolated from poultry and wild birds in Korea. The intravenous pathogenicity indices for the two representative viruses were both 3.0. Mortality of chickens intranasally inoculated with the two H5N8 viruses was 100% with a mean death times of 2.5 and 4.5 days. Mortality rates of the contact groups for the two H5N8 viruses were 33.3% and 66.6%. Our study showed that transmissibility of the novel H5N8 viruses was different from that of previously identified H5N1 HPAI viruses, possibly due to genetic changes.

Keyword

chicken; H5N8; highly pathogenic avian influenza; pathogenicity

MeSH Terms

Animals
Chickens
Disease Outbreaks/veterinary
Influenza A virus/*pathogenicity/*physiology
Influenza in Birds/*mortality/transmission/virology
Poultry Diseases/*mortality/transmission/virology
Republic of Korea/epidemiology
Virulence

Figure

• 

  Fig. 1 Survival curves for the experimentally inoculated and contact chickens. Eight 5-week-old chickens were inoculated with 106.5 EID50/0.1 mL of A/breeder duck/korea/Gochang 1/2014(H5N8) (Gochang1; A) or A/broiler duck/korea/Buan2/2014(H5N8) (Buan2; B). When comparing the survival curves of the two viruses, mortality rates were 100% for the inoculated chickens. There were significant differences between the survival curves of the two viruses for the contact chickens (log-rank test, p < 0.05).

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