Korean J Gastroenterol.
2016 May;67(5):267-271. 10.4166/kjg.2016.67.5.267.
Concomitant Drug Reaction with Eosinophilia and Systemic Symptom Syndrome from Ethambutol and Autoimmune Hepatitis from Isoniazid
- Affiliations
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- 1Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. nyheo@hanmail.net
- 2Department of Pathology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
- KMID: 2164335
- DOI: http://doi.org/10.4166/kjg.2016.67.5.267
Abstract
- Anti-tuberculosis drugs can produce levels of hepatotoxicity ranging from mild elevation of aminotransferase to severe acute hepatitis. A few cases of drug-induced autoimmune hepatitis or the drug reaction with eosinophilia and systemic symptom (DRESS) syndrome by anti-tuberculosis medications have been reported. However, concomitant occurrence of these two disorders has not been reported. Here, we present a case of severe acute hepatitis with DRESS syndrome and autoimmune hepatitis resulting from primary standard anti-tuberculosis drugs. Both conditions were successfully treated with a systemic steroid regimen.
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